Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis Patients
Background and purpose: Sambucus Ebulus plant is known for its anti-inflammatory and wound healing properties. This study aimed to determine the effect of Sambucus Ebulus Gel 5% on the severity and surface area of pruritus in hemodialysis patients. Materials and methods: A single-blind randomized cl...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2022-04-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-17949-en.html |
| _version_ | 1797893231608856576 |
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| author | Mohadese Saberian Majid Saeidi Mohammad Ali Ebrahimzadeh Seyed Nouraddin Mousavinasab Fatemeh Espahbodi Hedayat Jafari |
| author_facet | Mohadese Saberian Majid Saeidi Mohammad Ali Ebrahimzadeh Seyed Nouraddin Mousavinasab Fatemeh Espahbodi Hedayat Jafari |
| author_sort | Mohadese Saberian |
| collection | DOAJ |
| description | Background and purpose: Sambucus Ebulus plant is known for its anti-inflammatory and wound healing properties. This study aimed to determine the effect of Sambucus Ebulus Gel 5% on the severity and surface area of pruritus in hemodialysis patients.
Materials and methods: A single-blind randomized clinical trial was performed in 150 hemodialysis patients in three groups. We used Detailed Pruritus Score Introduced by Duo (1978) three times. The scale covers areas such as pruritus severity, distribution, frequency (morning and evening), and sleep disturbance. ANOVA test was used to compare the severity of pruritus between the three groups and Repeated Measure was used in each group.
Results: The mean itching score at the beginning of the study was not statistically significant in all groups (P= 0.49), but at weeks four and eight after treatment significant differences were seen between the three groups in mean score for pruritus severity (P=0.03 and P= 0.01, respectively). Acacia gel and placebo reduced the severity of itching (P= 0.00) but in control group no significant changes occurred (P= 0.158). Findings showed significant improvements in dry skin condition among the intervention and placebo groups (P= 0.00).
Conclusion: According to current study, Sambucus Ebulus Gel 5% can be considered as one of the topical treatments to relieve and improve uremic pruritus and dry skin in hemodialysis patients.
(Clinical Trials Registry Number: IRCT20191231045958N1) |
| first_indexed | 2024-04-10T06:49:34Z |
| format | Article |
| id | doaj.art-838e8cffc478498693424b404c19607d |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T06:49:34Z |
| publishDate | 2022-04-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-838e8cffc478498693424b404c19607d2023-02-28T08:28:00ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792022-04-01322085261Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis PatientsMohadese Saberian0Majid Saeidi1Mohammad Ali Ebrahimzadeh2Seyed Nouraddin Mousavinasab3Fatemeh Espahbodi4Hedayat Jafari5 MSc Student in Critical Care Nursing, Nasibeh Faculty of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran Professor, Department of Pharmaceutics, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Science Sciences, Sari, Iran Professor, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Biostatistics and Epidemiology, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Internal Medicine, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Medical Surgical Nursing, Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences Background and purpose: Sambucus Ebulus plant is known for its anti-inflammatory and wound healing properties. This study aimed to determine the effect of Sambucus Ebulus Gel 5% on the severity and surface area of pruritus in hemodialysis patients. Materials and methods: A single-blind randomized clinical trial was performed in 150 hemodialysis patients in three groups. We used Detailed Pruritus Score Introduced by Duo (1978) three times. The scale covers areas such as pruritus severity, distribution, frequency (morning and evening), and sleep disturbance. ANOVA test was used to compare the severity of pruritus between the three groups and Repeated Measure was used in each group. Results: The mean itching score at the beginning of the study was not statistically significant in all groups (P= 0.49), but at weeks four and eight after treatment significant differences were seen between the three groups in mean score for pruritus severity (P=0.03 and P= 0.01, respectively). Acacia gel and placebo reduced the severity of itching (P= 0.00) but in control group no significant changes occurred (P= 0.158). Findings showed significant improvements in dry skin condition among the intervention and placebo groups (P= 0.00). Conclusion: According to current study, Sambucus Ebulus Gel 5% can be considered as one of the topical treatments to relieve and improve uremic pruritus and dry skin in hemodialysis patients. (Clinical Trials Registry Number: IRCT20191231045958N1)http://jmums.mazums.ac.ir/article-1-17949-en.htmlchronic renal failureuremic pruritushemodialysissambucus ebulus |
| spellingShingle | Mohadese Saberian Majid Saeidi Mohammad Ali Ebrahimzadeh Seyed Nouraddin Mousavinasab Fatemeh Espahbodi Hedayat Jafari Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis Patients Journal of Mazandaran University of Medical Sciences chronic renal failure uremic pruritus hemodialysis sambucus ebulus |
| title | Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis Patients |
| title_full | Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis Patients |
| title_fullStr | Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis Patients |
| title_full_unstemmed | Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis Patients |
| title_short | Effect of Sambucus Ebulus Gel 5% on Severity and Surface Area of Uremic Pruritus in Hemodialysis Patients |
| title_sort | effect of sambucus ebulus gel 5 on severity and surface area of uremic pruritus in hemodialysis patients |
| topic | chronic renal failure uremic pruritus hemodialysis sambucus ebulus |
| url | http://jmums.mazums.ac.ir/article-1-17949-en.html |
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