Cofilin promotes tau pathology in Alzheimer’s disease

Cofilin promotes tau pathology in Alzheimer’s disease

Summary: The molecular mechanisms mediating the aggregation and transmission of tau in AD remain unclear. Here, we show that the actin-binding protein cofilin is cleaved by a cysteine protease asparagine endopeptidase (AEP) at N138 in the brains of patients with AD. The AEP-generated cofilin 1-138 f...

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Bibliographic Details
Main Authors: Mingmin Yan, Li Tang, Lijun Dai, Chuntao Lei, Min Xiong, Xingyu Zhang, Mingyang He, Ye Tian, Jing Xiong, Wei Ke, Zhaohui Zhang, Chun Zhang, Xiaorong Deng, Zhentao Zhang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723001493

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