Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury

Recent findings from the ISCoPe study indicate that, after severe contusion to the spinal cord, edema originating in the spinal cord accumulates and compresses the tissue against the surrounding dura mater, despite decompressive laminectomy. It is hypothesized that this compression results in restri...

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Main Authors: Christopher Hale, Jennifer Yonan, Ramsey Batarseh, Roman Chaar, Carrie R. Jonak, Shaokui Ge, Devin Binder, Victor G. J. Rodgers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00806/full
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author Christopher Hale
Jennifer Yonan
Ramsey Batarseh
Roman Chaar
Carrie R. Jonak
Shaokui Ge
Devin Binder
Victor G. J. Rodgers
author_facet Christopher Hale
Jennifer Yonan
Ramsey Batarseh
Roman Chaar
Carrie R. Jonak
Shaokui Ge
Devin Binder
Victor G. J. Rodgers
author_sort Christopher Hale
collection DOAJ
description Recent findings from the ISCoPe study indicate that, after severe contusion to the spinal cord, edema originating in the spinal cord accumulates and compresses the tissue against the surrounding dura mater, despite decompressive laminectomy. It is hypothesized that this compression results in restricted flow of cerebrospinal fluid (CSF) in the subarachnoid space and central canal and ultimately collapses local vasculature, exacerbating ischemia and secondary injury. Here we developed a surgically mounted osmotic transport device (OTD) that rests on the dura and can osmotically remove excess fluid at the injury site. Tests were performed in 4-h studies immediately following severe (250 kD) contusion at T8 in rats using the OTD. A 3-h treatment with the OTD after 1-h post injury significantly reduced spinal cord edema compared to injured controls. A first approximation mathematical interpretation implies that this modest reduction in edema may be significant enough to relieve compression of local vasculature and restore flow of CSF in the region. In addition, we determined the progression of edema up to 28 days after insult in the rat for the same injury model. Results showed peak edema at 72 h. These preliminary results suggest that incorporating the OTD to operate continuously at the site of injury throughout the critical period of edema progression, the device may significantly improve recovery following contusion spinal cord injury.
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spelling doaj.art-838f4c25bdb241109df1be89d5df8fd52022-12-22T00:22:50ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-07-01810.3389/fbioe.2020.00806553651Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord InjuryChristopher Hale0Jennifer Yonan1Ramsey Batarseh2Roman Chaar3Carrie R. Jonak4Shaokui Ge5Devin Binder6Victor G. J. Rodgers7Department of Bioengineering, University of California, Riverside, Riverside, CA, United StatesDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDepartment of Bioengineering, University of California, Riverside, Riverside, CA, United StatesDepartment of Bioengineering, University of California, Riverside, Riverside, CA, United StatesDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDivision of Biostatistics & Bioinformatics, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDepartment of Bioengineering, University of California, Riverside, Riverside, CA, United StatesRecent findings from the ISCoPe study indicate that, after severe contusion to the spinal cord, edema originating in the spinal cord accumulates and compresses the tissue against the surrounding dura mater, despite decompressive laminectomy. It is hypothesized that this compression results in restricted flow of cerebrospinal fluid (CSF) in the subarachnoid space and central canal and ultimately collapses local vasculature, exacerbating ischemia and secondary injury. Here we developed a surgically mounted osmotic transport device (OTD) that rests on the dura and can osmotically remove excess fluid at the injury site. Tests were performed in 4-h studies immediately following severe (250 kD) contusion at T8 in rats using the OTD. A 3-h treatment with the OTD after 1-h post injury significantly reduced spinal cord edema compared to injured controls. A first approximation mathematical interpretation implies that this modest reduction in edema may be significant enough to relieve compression of local vasculature and restore flow of CSF in the region. In addition, we determined the progression of edema up to 28 days after insult in the rat for the same injury model. Results showed peak edema at 72 h. These preliminary results suggest that incorporating the OTD to operate continuously at the site of injury throughout the critical period of edema progression, the device may significantly improve recovery following contusion spinal cord injury.https://www.frontiersin.org/article/10.3389/fbioe.2020.00806/fullspinal cord injuryedemasevere contusionimplantable devicemembrane separationsosmotic transport device (OTD)
spellingShingle Christopher Hale
Jennifer Yonan
Ramsey Batarseh
Roman Chaar
Carrie R. Jonak
Shaokui Ge
Devin Binder
Victor G. J. Rodgers
Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury
Frontiers in Bioengineering and Biotechnology
spinal cord injury
edema
severe contusion
implantable device
membrane separations
osmotic transport device (OTD)
title Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury
title_full Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury
title_fullStr Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury
title_full_unstemmed Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury
title_short Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury
title_sort implantable osmotic transport device can reduce edema after severe contusion spinal cord injury
topic spinal cord injury
edema
severe contusion
implantable device
membrane separations
osmotic transport device (OTD)
url https://www.frontiersin.org/article/10.3389/fbioe.2020.00806/full
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