Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury
Recent findings from the ISCoPe study indicate that, after severe contusion to the spinal cord, edema originating in the spinal cord accumulates and compresses the tissue against the surrounding dura mater, despite decompressive laminectomy. It is hypothesized that this compression results in restri...
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Frontiers Media S.A.
2020-07-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00806/full |
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author | Christopher Hale Jennifer Yonan Ramsey Batarseh Roman Chaar Carrie R. Jonak Shaokui Ge Devin Binder Victor G. J. Rodgers |
author_facet | Christopher Hale Jennifer Yonan Ramsey Batarseh Roman Chaar Carrie R. Jonak Shaokui Ge Devin Binder Victor G. J. Rodgers |
author_sort | Christopher Hale |
collection | DOAJ |
description | Recent findings from the ISCoPe study indicate that, after severe contusion to the spinal cord, edema originating in the spinal cord accumulates and compresses the tissue against the surrounding dura mater, despite decompressive laminectomy. It is hypothesized that this compression results in restricted flow of cerebrospinal fluid (CSF) in the subarachnoid space and central canal and ultimately collapses local vasculature, exacerbating ischemia and secondary injury. Here we developed a surgically mounted osmotic transport device (OTD) that rests on the dura and can osmotically remove excess fluid at the injury site. Tests were performed in 4-h studies immediately following severe (250 kD) contusion at T8 in rats using the OTD. A 3-h treatment with the OTD after 1-h post injury significantly reduced spinal cord edema compared to injured controls. A first approximation mathematical interpretation implies that this modest reduction in edema may be significant enough to relieve compression of local vasculature and restore flow of CSF in the region. In addition, we determined the progression of edema up to 28 days after insult in the rat for the same injury model. Results showed peak edema at 72 h. These preliminary results suggest that incorporating the OTD to operate continuously at the site of injury throughout the critical period of edema progression, the device may significantly improve recovery following contusion spinal cord injury. |
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spelling | doaj.art-838f4c25bdb241109df1be89d5df8fd52022-12-22T00:22:50ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-07-01810.3389/fbioe.2020.00806553651Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord InjuryChristopher Hale0Jennifer Yonan1Ramsey Batarseh2Roman Chaar3Carrie R. Jonak4Shaokui Ge5Devin Binder6Victor G. J. Rodgers7Department of Bioengineering, University of California, Riverside, Riverside, CA, United StatesDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDepartment of Bioengineering, University of California, Riverside, Riverside, CA, United StatesDepartment of Bioengineering, University of California, Riverside, Riverside, CA, United StatesDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDivision of Biostatistics & Bioinformatics, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United StatesDepartment of Bioengineering, University of California, Riverside, Riverside, CA, United StatesRecent findings from the ISCoPe study indicate that, after severe contusion to the spinal cord, edema originating in the spinal cord accumulates and compresses the tissue against the surrounding dura mater, despite decompressive laminectomy. It is hypothesized that this compression results in restricted flow of cerebrospinal fluid (CSF) in the subarachnoid space and central canal and ultimately collapses local vasculature, exacerbating ischemia and secondary injury. Here we developed a surgically mounted osmotic transport device (OTD) that rests on the dura and can osmotically remove excess fluid at the injury site. Tests were performed in 4-h studies immediately following severe (250 kD) contusion at T8 in rats using the OTD. A 3-h treatment with the OTD after 1-h post injury significantly reduced spinal cord edema compared to injured controls. A first approximation mathematical interpretation implies that this modest reduction in edema may be significant enough to relieve compression of local vasculature and restore flow of CSF in the region. In addition, we determined the progression of edema up to 28 days after insult in the rat for the same injury model. Results showed peak edema at 72 h. These preliminary results suggest that incorporating the OTD to operate continuously at the site of injury throughout the critical period of edema progression, the device may significantly improve recovery following contusion spinal cord injury.https://www.frontiersin.org/article/10.3389/fbioe.2020.00806/fullspinal cord injuryedemasevere contusionimplantable devicemembrane separationsosmotic transport device (OTD) |
spellingShingle | Christopher Hale Jennifer Yonan Ramsey Batarseh Roman Chaar Carrie R. Jonak Shaokui Ge Devin Binder Victor G. J. Rodgers Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury Frontiers in Bioengineering and Biotechnology spinal cord injury edema severe contusion implantable device membrane separations osmotic transport device (OTD) |
title | Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury |
title_full | Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury |
title_fullStr | Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury |
title_full_unstemmed | Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury |
title_short | Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury |
title_sort | implantable osmotic transport device can reduce edema after severe contusion spinal cord injury |
topic | spinal cord injury edema severe contusion implantable device membrane separations osmotic transport device (OTD) |
url | https://www.frontiersin.org/article/10.3389/fbioe.2020.00806/full |
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