Molecular Classifiers in Skin Cancers: Challenges and Promises
Skin cancers are common and heterogenous malignancies affecting up to two in three Australians before age 70. Despite recent developments in diagnosis and therapeutic strategies, the mortality rate and costs associated with managing patients with skin cancers remain high. The lack of well-defined cl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/18/4463 |
| _version_ | 1797580950908960768 |
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| author | Ali Azimi Pablo Fernandez-Peñas |
| author_facet | Ali Azimi Pablo Fernandez-Peñas |
| author_sort | Ali Azimi |
| collection | DOAJ |
| description | Skin cancers are common and heterogenous malignancies affecting up to two in three Australians before age 70. Despite recent developments in diagnosis and therapeutic strategies, the mortality rate and costs associated with managing patients with skin cancers remain high. The lack of well-defined clinical and histopathological features makes their diagnosis and classification difficult in some cases and the prognostication difficult in most skin cancers. Recent advancements in large-scale “omics” studies, including genomics, transcriptomics, proteomics, metabolomics and imaging-omics, have provided invaluable information about the molecular and visual landscape of skin cancers. On many occasions, it has refined tumor classification and has improved prognostication and therapeutic stratification, leading to improved patient outcomes. Therefore, this paper reviews the recent advancements in omics approaches and appraises their limitations and potential for better classification and stratification of skin cancers. |
| first_indexed | 2024-03-10T22:57:23Z |
| format | Article |
| id | doaj.art-838f741ffaf44df396671a6f3d27cc29 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T22:57:23Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-838f741ffaf44df396671a6f3d27cc292023-11-19T09:54:09ZengMDPI AGCancers2072-66942023-09-011518446310.3390/cancers15184463Molecular Classifiers in Skin Cancers: Challenges and PromisesAli Azimi0Pablo Fernandez-Peñas1Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW 2145, AustraliaWestmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW 2145, AustraliaSkin cancers are common and heterogenous malignancies affecting up to two in three Australians before age 70. Despite recent developments in diagnosis and therapeutic strategies, the mortality rate and costs associated with managing patients with skin cancers remain high. The lack of well-defined clinical and histopathological features makes their diagnosis and classification difficult in some cases and the prognostication difficult in most skin cancers. Recent advancements in large-scale “omics” studies, including genomics, transcriptomics, proteomics, metabolomics and imaging-omics, have provided invaluable information about the molecular and visual landscape of skin cancers. On many occasions, it has refined tumor classification and has improved prognostication and therapeutic stratification, leading to improved patient outcomes. Therefore, this paper reviews the recent advancements in omics approaches and appraises their limitations and potential for better classification and stratification of skin cancers.https://www.mdpi.com/2072-6694/15/18/4463skin cancermolecular classifiermelanomabasal cell carcinomacutaneous squamous-cell carcinoma |
| spellingShingle | Ali Azimi Pablo Fernandez-Peñas Molecular Classifiers in Skin Cancers: Challenges and Promises Cancers skin cancer molecular classifier melanoma basal cell carcinoma cutaneous squamous-cell carcinoma |
| title | Molecular Classifiers in Skin Cancers: Challenges and Promises |
| title_full | Molecular Classifiers in Skin Cancers: Challenges and Promises |
| title_fullStr | Molecular Classifiers in Skin Cancers: Challenges and Promises |
| title_full_unstemmed | Molecular Classifiers in Skin Cancers: Challenges and Promises |
| title_short | Molecular Classifiers in Skin Cancers: Challenges and Promises |
| title_sort | molecular classifiers in skin cancers challenges and promises |
| topic | skin cancer molecular classifier melanoma basal cell carcinoma cutaneous squamous-cell carcinoma |
| url | https://www.mdpi.com/2072-6694/15/18/4463 |
| work_keys_str_mv | AT aliazimi molecularclassifiersinskincancerschallengesandpromises AT pablofernandezpenas molecularclassifiersinskincancerschallengesandpromises |