ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer

ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer

The induction of ferroptosis is promising for cancer therapy. However, the mechanisms enabling cancer cells to evade ferroptosis, particularly in low-cystine environments, remain elusive. Our study delves into the intricate regulatory mechanisms of Activating transcription factor 3 (ATF3) on Cystath...

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Bibliographic Details
Main Authors: Junjia Liu, Xinyi Lu, Siyu Zeng, Rong Fu, Xindong Wang, Lingtao Luo, Ting Huang, Xusheng Deng, Hualei Zheng, Shaoqian Ma, Dan Ning, Lili Zong, Shu-Hai Lin, Yongyou Zhang
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Redox Biology
Subjects:
Ferroptosis
Colorectal cancer (CRC)
ATF3-CBS signaling axis
Mitochondrial tricarboxylic acid (TCA) cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000946

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