GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
Growth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18500-x |
| _version_ | 1828972486642892800 |
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| author | Dayana Abboud Adrian F. Daly Nadine Dupuis Mohamed Ali Bahri Asuka Inoue Andy Chevigné Fabien Ectors Alain Plenevaux Bernard Pirotte Albert Beckers Julien Hanson |
| author_facet | Dayana Abboud Adrian F. Daly Nadine Dupuis Mohamed Ali Bahri Asuka Inoue Andy Chevigné Fabien Ectors Alain Plenevaux Bernard Pirotte Albert Beckers Julien Hanson |
| author_sort | Dayana Abboud |
| collection | DOAJ |
| description | Growth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways. |
| first_indexed | 2024-12-14T13:28:57Z |
| format | Article |
| id | doaj.art-839017688b1d4d559b0f157b0b3d14dd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:28:57Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-839017688b1d4d559b0f157b0b3d14dd2022-12-21T22:59:45ZengNature PortfolioNature Communications2041-17232020-09-0111111610.1038/s41467-020-18500-xGPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11Dayana Abboud0Adrian F. Daly1Nadine Dupuis2Mohamed Ali Bahri3Asuka Inoue4Andy Chevigné5Fabien Ectors6Alain Plenevaux7Bernard Pirotte8Albert Beckers9Julien Hanson10Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of LiègeDepartment of Endocrinology, Centre Hospitalier Universitaire de Liège, University of LiègeLaboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of LiègeGIGA-CRC in vivo Imaging, University of LiègeGraduate School of Pharmaceutical Sciences, Tohoku UniversityImmuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of HealthGIGA—Transgenics Platform, Liège UniversityGIGA-CRC in vivo Imaging, University of LiègeLaboratory of Medicinal Chemistry, Centre for Interdisciplinary Research on Medicines (CIRM), University of LiègeDepartment of Endocrinology, Centre Hospitalier Universitaire de Liège, University of LiègeLaboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of LiègeGrowth hormone (GH) is a major modulator of physical growth and metabolism that is under tight regulatory control. Here the authors describe the signaling profile of GPR101, an orphan receptor that enhances GH secretion principally via constitutively activated Gs-PKA and Gq/11-PKC pathways.https://doi.org/10.1038/s41467-020-18500-x |
| spellingShingle | Dayana Abboud Adrian F. Daly Nadine Dupuis Mohamed Ali Bahri Asuka Inoue Andy Chevigné Fabien Ectors Alain Plenevaux Bernard Pirotte Albert Beckers Julien Hanson GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 Nature Communications |
| title | GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 |
| title_full | GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 |
| title_fullStr | GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 |
| title_full_unstemmed | GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 |
| title_short | GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 |
| title_sort | gpr101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of gs and gq 11 |
| url | https://doi.org/10.1038/s41467-020-18500-x |
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