Sickle Cell Diseases
Sickle cell diseases (SCDs) are chronic destructive process on endothelium particularly at the capillary level. The chronic catastrophic process initiates at birth, and terminates with accelerated endotelial damage induced multiorgan failures in early years of life. Chronic obstructive pulmonary dis...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mustafa Kemal University
2015-07-01
|
| Series: | Mustafa Kemal Üniversitesi Tıp Dergisi |
| Subjects: | |
| Online Access: | http://dergipark.gov.tr/mkutfd/issue/19601/209503?publisher=mku |
| _version_ | 1797917183632736256 |
|---|---|
| author | Mehmet Helvaci |
| author_facet | Mehmet Helvaci |
| author_sort | Mehmet Helvaci |
| collection | DOAJ |
| description | Sickle cell diseases (SCDs) are chronic destructive process on endothelium particularly at the capillary level. The chronic catastrophic process initiates at birth, and terminates with accelerated endotelial damage induced multiorgan failures in early years of life. Chronic obstructive pulmonary disease, leg ulcers, digital clubbing, priapism, coronary heart disease, chronic renal disease, peripheric artery disease, cirrhosis, and stroke are just some of the terminal end points of the diseases. Red blood cell transfusions should be the treatment of choice nearly in all acute events and emergencies of the diseases to prevent disseminated tissue hypoxia all over the body. In long term treatment, an oral hydroxyurea is cheap, safe, and effective drug, not to prevent but to delay the end points of the diseases.Key Words: Sickle cell diseases, chronic endothelial inflammation |
| first_indexed | 2024-04-10T13:09:18Z |
| format | Article |
| id | doaj.art-8391c5c7546a400e8a2c4e9e0eb77531 |
| institution | Directory Open Access Journal |
| issn | 2149-3103 |
| language | English |
| last_indexed | 2024-04-10T13:09:18Z |
| publishDate | 2015-07-01 |
| publisher | Mustafa Kemal University |
| record_format | Article |
| series | Mustafa Kemal Üniversitesi Tıp Dergisi |
| spelling | doaj.art-8391c5c7546a400e8a2c4e9e0eb775312023-02-15T16:12:40ZengMustafa Kemal UniversityMustafa Kemal Üniversitesi Tıp Dergisi2149-31032015-07-01622253410.17944/mkutfd.34012102Sickle Cell DiseasesMehmet HelvaciSickle cell diseases (SCDs) are chronic destructive process on endothelium particularly at the capillary level. The chronic catastrophic process initiates at birth, and terminates with accelerated endotelial damage induced multiorgan failures in early years of life. Chronic obstructive pulmonary disease, leg ulcers, digital clubbing, priapism, coronary heart disease, chronic renal disease, peripheric artery disease, cirrhosis, and stroke are just some of the terminal end points of the diseases. Red blood cell transfusions should be the treatment of choice nearly in all acute events and emergencies of the diseases to prevent disseminated tissue hypoxia all over the body. In long term treatment, an oral hydroxyurea is cheap, safe, and effective drug, not to prevent but to delay the end points of the diseases.Key Words: Sickle cell diseases, chronic endothelial inflammationhttp://dergipark.gov.tr/mkutfd/issue/19601/209503?publisher=mku-Sickle cell diseases chronic endothelial inflammationOrak hücre hastalıkları kronik endotel iltihabı |
| spellingShingle | Mehmet Helvaci Sickle Cell Diseases Mustafa Kemal Üniversitesi Tıp Dergisi - Sickle cell diseases chronic endothelial inflammation Orak hücre hastalıkları kronik endotel iltihabı |
| title | Sickle Cell Diseases |
| title_full | Sickle Cell Diseases |
| title_fullStr | Sickle Cell Diseases |
| title_full_unstemmed | Sickle Cell Diseases |
| title_short | Sickle Cell Diseases |
| title_sort | sickle cell diseases |
| topic | - Sickle cell diseases chronic endothelial inflammation Orak hücre hastalıkları kronik endotel iltihabı |
| url | http://dergipark.gov.tr/mkutfd/issue/19601/209503?publisher=mku |
| work_keys_str_mv | AT mehmethelvaci sicklecelldiseases |