Determination of galectin-3 expression in the tissue of follicular thyroid tumors
The aim of this study was to investigate the usefulness of immunohistochemical expression galectin-3 for differential diagnosis follicular carcinoma and follicular adenoma in a sample of thyroid lesions using a specific antigalectin-3 monoclonal antibody. We evaluated 36 thyroid lesions including 15...
| Format: | Article |
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| Language: | Russian |
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Endocrinology Research Centre
2011-03-01
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| Series: | Клиническая и экспериментальная тиреоидология |
| Subjects: | |
| Online Access: | https://cet-endojournals.ru/ket/article/viewFile/4323/2450 |
| _version_ | 1819132131755950080 |
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| collection | DOAJ |
| description | The aim of this study was to investigate the usefulness of immunohistochemical expression galectin-3 for differential diagnosis follicular carcinoma and follicular adenoma in a sample of thyroid lesions using a specific antigalectin-3 monoclonal antibody. We evaluated 36 thyroid lesions including 15 follicular carcinomas, 15 follicular adenomas, and in 6 cases there was a combination of follicular carcinomas and follicular adenomas. Galectin-3 expression was detected in 8 of 15 (53.3%) follicular adenomas, 13 of 15 (86.7%) follicular carcinomas and in 6 of6 (100%) combined cases. The sensitivity, specificity, efficiency and diagnostic accuracy of this test method were73.6%, 81.8%, 77.7% and 77%, respectively. Galectin-3 expression determined in 53.3% of adenomas. The average level of the expression in adenoma cells was significantly lower compared with carcinoma. Galectin-3 can’t be used for differential immunohistochemical diagnosis of follicular thyroid tumors because the expression of the marker in cells of follicular carcinoma was only 86.7%. Expression of galectin-3 in the cells of adenomas with a combination of follicular adenoma and follicular cancer was revealed in all cases. In the adenoma tissue mean expression level was significantly lower than in carcinoma. So galectin-3 can’t be used as the sole marker but definition of the expression galectin-3 may be important in the complex diagnosis follicular thyroid tumors and also in combination with other markers. The expression of galectin-3 chance of having a malignant nature of the tumor was significantly higher. |
| first_indexed | 2024-12-22T09:26:32Z |
| format | Article |
| id | doaj.art-8392553368304a5d9f352e1332042832 |
| institution | Directory Open Access Journal |
| issn | 1995-5472 2310-3787 |
| language | Russian |
| last_indexed | 2024-12-22T09:26:32Z |
| publishDate | 2011-03-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Клиническая и экспериментальная тиреоидология |
| spelling | doaj.art-8392553368304a5d9f352e13320428322022-12-21T18:31:04ZrusEndocrinology Research CentreКлиническая и экспериментальная тиреоидология1995-54722310-37872011-03-0171454910.14341/ket20117145-494281Determination of galectin-3 expression in the tissue of follicular thyroid tumorsThe aim of this study was to investigate the usefulness of immunohistochemical expression galectin-3 for differential diagnosis follicular carcinoma and follicular adenoma in a sample of thyroid lesions using a specific antigalectin-3 monoclonal antibody. We evaluated 36 thyroid lesions including 15 follicular carcinomas, 15 follicular adenomas, and in 6 cases there was a combination of follicular carcinomas and follicular adenomas. Galectin-3 expression was detected in 8 of 15 (53.3%) follicular adenomas, 13 of 15 (86.7%) follicular carcinomas and in 6 of6 (100%) combined cases. The sensitivity, specificity, efficiency and diagnostic accuracy of this test method were73.6%, 81.8%, 77.7% and 77%, respectively. Galectin-3 expression determined in 53.3% of adenomas. The average level of the expression in adenoma cells was significantly lower compared with carcinoma. Galectin-3 can’t be used for differential immunohistochemical diagnosis of follicular thyroid tumors because the expression of the marker in cells of follicular carcinoma was only 86.7%. Expression of galectin-3 in the cells of adenomas with a combination of follicular adenoma and follicular cancer was revealed in all cases. In the adenoma tissue mean expression level was significantly lower than in carcinoma. So galectin-3 can’t be used as the sole marker but definition of the expression galectin-3 may be important in the complex diagnosis follicular thyroid tumors and also in combination with other markers. The expression of galectin-3 chance of having a malignant nature of the tumor was significantly higher.https://cet-endojournals.ru/ket/article/viewFile/4323/2450galectin-3follicular adenomafollicular carcinomaimmuno-histochemicalthyroid tumors |
| spellingShingle | Determination of galectin-3 expression in the tissue of follicular thyroid tumors Клиническая и экспериментальная тиреоидология galectin-3 follicular adenoma follicular carcinoma immuno-histochemical thyroid tumors |
| title | Determination of galectin-3 expression in the tissue of follicular thyroid tumors |
| title_full | Determination of galectin-3 expression in the tissue of follicular thyroid tumors |
| title_fullStr | Determination of galectin-3 expression in the tissue of follicular thyroid tumors |
| title_full_unstemmed | Determination of galectin-3 expression in the tissue of follicular thyroid tumors |
| title_short | Determination of galectin-3 expression in the tissue of follicular thyroid tumors |
| title_sort | determination of galectin 3 expression in the tissue of follicular thyroid tumors |
| topic | galectin-3 follicular adenoma follicular carcinoma immuno-histochemical thyroid tumors |
| url | https://cet-endojournals.ru/ket/article/viewFile/4323/2450 |