Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis

Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis

The crosstalk between the BM microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration. Here, we show that in mice, deletion of the Fanconi anemia (FA) genes Fanca and Fancc dampened HSC regeneration through direct effects on HSCs and indirect effects on BM niche...

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Bibliographic Details
Main Authors: Qiqi Lin, Limei Wu, Srinivas Chatla, Fabliha A. Chowdhury, Neha Atale, Jonathan Joseph, Wei Du
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-06-01
Series:The Journal of Clinical Investigation
Subjects:
Cell biology
Hematology
Online Access:https://doi.org/10.1172/JCI155914

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