Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition
Highlights 1. In a fully counterbalanced (for sex and all experimental conditions), sham-controlled cross-over study, we examined the effects of tDCS over the left DLPFC in the context of Stop-Signal task. 2. The effects of tDCS on response inhibition was uniform across both males and females. 3. Th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-08-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-021-00390-3 |
| _version_ | 1819124910316847104 |
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| author | Daniel J. Fehring Ranshikha Samandra Zakia Z. Haque Shapour Jaberzadeh Marcello Rosa Farshad A. Mansouri |
| author_facet | Daniel J. Fehring Ranshikha Samandra Zakia Z. Haque Shapour Jaberzadeh Marcello Rosa Farshad A. Mansouri |
| author_sort | Daniel J. Fehring |
| collection | DOAJ |
| description | Highlights 1. In a fully counterbalanced (for sex and all experimental conditions), sham-controlled cross-over study, we examined the effects of tDCS over the left DLPFC in the context of Stop-Signal task. 2. The effects of tDCS on response inhibition was uniform across both males and females. 3. The effects of tDCS on response execution differed in males and females. 4. The tDCS mainly modulated the practice-related (learning-related) changes in participants’ performance, but these effects of tDCS were different between males and females. 5. These findings highlight the need to adequately control for participants' sex and the need to develop sex-specific tDCS protocols in clinical settings. |
| first_indexed | 2024-12-22T07:31:45Z |
| format | Article |
| id | doaj.art-8395d49ae77d48b3b3ec283137764158 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-12-22T07:31:45Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-8395d49ae77d48b3b3ec2831377641582022-12-21T18:34:00ZengBMCBiology of Sex Differences2042-64102021-08-0112111510.1186/s13293-021-00390-3Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibitionDaniel J. Fehring0Ranshikha Samandra1Zakia Z. Haque2Shapour Jaberzadeh3Marcello Rosa4Farshad A. Mansouri5Cognitive Neuroscience Laboratory, Monash Biomedicine Discovery Institute, Department of Physiology, Monash UniversityCognitive Neuroscience Laboratory, Monash Biomedicine Discovery Institute, Department of Physiology, Monash UniversityCognitive Neuroscience Laboratory, Monash Biomedicine Discovery Institute, Department of Physiology, Monash UniversityDepartment of Physiotherapy, Non-Invasive Brain Stimulation & Neuroplasticity Laboratory, Monash UniversityARC Centre of Excellence in Integrative Brain Function, Monash UniversityCognitive Neuroscience Laboratory, Monash Biomedicine Discovery Institute, Department of Physiology, Monash UniversityHighlights 1. In a fully counterbalanced (for sex and all experimental conditions), sham-controlled cross-over study, we examined the effects of tDCS over the left DLPFC in the context of Stop-Signal task. 2. The effects of tDCS on response inhibition was uniform across both males and females. 3. The effects of tDCS on response execution differed in males and females. 4. The tDCS mainly modulated the practice-related (learning-related) changes in participants’ performance, but these effects of tDCS were different between males and females. 5. These findings highlight the need to adequately control for participants' sex and the need to develop sex-specific tDCS protocols in clinical settings.https://doi.org/10.1186/s13293-021-00390-3Sex dependency of cognitive functionsBrain stimulationLearningStop-Signal Task |
| spellingShingle | Daniel J. Fehring Ranshikha Samandra Zakia Z. Haque Shapour Jaberzadeh Marcello Rosa Farshad A. Mansouri Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition Biology of Sex Differences Sex dependency of cognitive functions Brain stimulation Learning Stop-Signal Task |
| title | Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition |
| title_full | Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition |
| title_fullStr | Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition |
| title_full_unstemmed | Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition |
| title_short | Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition |
| title_sort | investigating the sex dependent effects of prefrontal cortex stimulation on response execution and inhibition |
| topic | Sex dependency of cognitive functions Brain stimulation Learning Stop-Signal Task |
| url | https://doi.org/10.1186/s13293-021-00390-3 |
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