STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM
The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude ex...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2013-10-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/618/493 |
| _version_ | 1811269516842237952 |
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| author | Bishwajit Bokshi Md.Nazmul Hasan Zilani Aparajita Malakar Debendra Nath Roy Jamil Ahmad Shilpi Samir Kumar Sadhu |
| author_facet | Bishwajit Bokshi Md.Nazmul Hasan Zilani Aparajita Malakar Debendra Nath Roy Jamil Ahmad Shilpi Samir Kumar Sadhu |
| author_sort | Bishwajit Bokshi |
| collection | DOAJ |
| description | The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500mg/kg BW comparable to the standard drug diclofenac sodium at the dose of 25mg/kg BW. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 250 and 500mg/kg BW comparable to the standard drug loperamide at the dose of 50mg/kg BW. The overall results tend to suggest the analgesic and antidiarrhoeal activities of the different fractions of crude extract. Both ethyl acetate fraction of stem and chloroform fraction of leaf have significant analgesic activity. Again between the two fractions of crude ethanol extract ethyl acetate fraction of S.caseolaris stem have most significant antidiarrhoeal activity. |
| first_indexed | 2024-04-12T21:43:28Z |
| format | Article |
| id | doaj.art-8397b59def1e4d349aa07eea728d7b1b |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-04-12T21:43:28Z |
| publishDate | 2013-10-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-8397b59def1e4d349aa07eea728d7b1b2022-12-22T03:15:42ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862013-10-01244253258http://dx.doi.org/10.14499/indonesianjpharm0iss0pp253-258STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEMBishwajit Bokshi0Md.Nazmul Hasan Zilani1Aparajita Malakar2Debendra Nath Roy3Jamil Ahmad Shilpi4Samir Kumar Sadhu5Pharmacy Discipline, Khulna University, Khulna, Khulna-9208 BangladeshPharmacy Discipline, Khulna University, Khulna, Khulna-9208 BangladeshPharmacy Discipline, Khulna University, Khulna, Khulna-9208 BangladeshPharmacy, Jessore Science and Technology University, Independence Road), 7408- Bangladesh Pharmacy Discipline, Khulna University, Khulna, Khulna-9208 BangladeshPharmacy Discipline, Khulna University, Khulna, Khulna-9208 BangladeshThe different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500mg/kg BW comparable to the standard drug diclofenac sodium at the dose of 25mg/kg BW. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 250 and 500mg/kg BW comparable to the standard drug loperamide at the dose of 50mg/kg BW. The overall results tend to suggest the analgesic and antidiarrhoeal activities of the different fractions of crude extract. Both ethyl acetate fraction of stem and chloroform fraction of leaf have significant analgesic activity. Again between the two fractions of crude ethanol extract ethyl acetate fraction of S.caseolaris stem have most significant antidiarrhoeal activity.https://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/618/493analgesicantidiarrhoealS.caseolarisdiclofenac sodiumloperamide |
| spellingShingle | Bishwajit Bokshi Md.Nazmul Hasan Zilani Aparajita Malakar Debendra Nath Roy Jamil Ahmad Shilpi Samir Kumar Sadhu STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM Indonesian Journal of Pharmacy analgesic antidiarrhoeal S.caseolaris diclofenac sodium loperamide |
| title | STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM |
| title_full | STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM |
| title_fullStr | STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM |
| title_full_unstemmed | STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM |
| title_short | STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM |
| title_sort | study of analgesic and antidiarrhoeal activities of sonneratia caseolaris linn leaf and stem using different solvent system |
| topic | analgesic antidiarrhoeal S.caseolaris diclofenac sodium loperamide |
| url | https://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/618/493 |
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