Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice
<i>Lactarius hatsudake</i> (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined...
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MDPI AG
2024-03-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/6/948 |
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| author | Hanyu Zhu Tao Hou |
| author_facet | Hanyu Zhu Tao Hou |
| author_sort | Hanyu Zhu |
| collection | DOAJ |
| description | <i>Lactarius hatsudake</i> (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels. Additionally, it positively influenced gut microbiota to resemble that of mice on a normal diet. In HFD-fed mice, LH markedly boosted the levels of <i>Parabacteroides</i>, unclassified <i>Muribaculaceae</i>, <i>Oscillibacter</i>, and unclassified <i>Oscillospiraceae</i>, while reducing the abundance of <i>Lachnospiraceae NK4A136</i> group and <i>Erysipelatoclostridium</i>, as well as the ratio of Firmicutes to Bacteroidetes. Further analysis of correlation indicate a possible connection between obesity and gut microbiota. Obesity-related indices show a positive association with unclassified <i>Eubacterium coprostanoligenes</i> group, <i>Blautia</i>, and <i>Erysipelatoclostridium</i>, while displaying a negative correlation with unclassified <i>Muribaculaceae</i>, unclassified <i>Clostridia vadinBB60</i> group, <i>Helicobacter</i>, <i>Oscillibacter</i>, unclassified <i>Ruminococcaceae</i>, <i>Parabacteroides</i>, and unclassified <i>Oscillospiraceae</i>. The results suggest that LH can help combat obesity and may have the potential to be utilized as a functional food. |
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| format | Article |
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| language | English |
| last_indexed | 2024-04-24T18:17:03Z |
| publishDate | 2024-03-01 |
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| series | Foods |
| spelling | doaj.art-839cfbf29ece40d2b3c9dad7e40aec302024-03-27T13:41:16ZengMDPI AGFoods2304-81582024-03-0113694810.3390/foods13060948Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 MiceHanyu Zhu0Tao Hou1College of Life Science, Hengyang Normal University, Hengyang 421000, ChinaCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China<i>Lactarius hatsudake</i> (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels. Additionally, it positively influenced gut microbiota to resemble that of mice on a normal diet. In HFD-fed mice, LH markedly boosted the levels of <i>Parabacteroides</i>, unclassified <i>Muribaculaceae</i>, <i>Oscillibacter</i>, and unclassified <i>Oscillospiraceae</i>, while reducing the abundance of <i>Lachnospiraceae NK4A136</i> group and <i>Erysipelatoclostridium</i>, as well as the ratio of Firmicutes to Bacteroidetes. Further analysis of correlation indicate a possible connection between obesity and gut microbiota. Obesity-related indices show a positive association with unclassified <i>Eubacterium coprostanoligenes</i> group, <i>Blautia</i>, and <i>Erysipelatoclostridium</i>, while displaying a negative correlation with unclassified <i>Muribaculaceae</i>, unclassified <i>Clostridia vadinBB60</i> group, <i>Helicobacter</i>, <i>Oscillibacter</i>, unclassified <i>Ruminococcaceae</i>, <i>Parabacteroides</i>, and unclassified <i>Oscillospiraceae</i>. The results suggest that LH can help combat obesity and may have the potential to be utilized as a functional food.https://www.mdpi.com/2304-8158/13/6/948<i>Lactarius hatsudake</i>biochemical indexgut microbiotacorrelation analysisobesity |
| spellingShingle | Hanyu Zhu Tao Hou Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice Foods <i>Lactarius hatsudake</i> biochemical index gut microbiota correlation analysis obesity |
| title | Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice |
| title_full | Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice |
| title_fullStr | Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice |
| title_full_unstemmed | Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice |
| title_short | Modulatory Effects of <i>Lactarius hatsudake</i> on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice |
| title_sort | modulatory effects of i lactarius hatsudake i on obesity and gut microbiota in high fat diet fed c57bl 6 mice |
| topic | <i>Lactarius hatsudake</i> biochemical index gut microbiota correlation analysis obesity |
| url | https://www.mdpi.com/2304-8158/13/6/948 |
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