SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis
Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes, and their development is intricately connected to the disruption of the JAK-STAT signaling pathway, where SOCS proteins play crucial roles. Conditions such as autoimmune uveitis, psoriasis, lupus, and autoimmu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1271102/full |
| _version_ | 1827782598251773952 |
|---|---|
| author | Rahul Pandey Marina Bakay Hakon Hakonarson Hakon Hakonarson |
| author_facet | Rahul Pandey Marina Bakay Hakon Hakonarson Hakon Hakonarson |
| author_sort | Rahul Pandey |
| collection | DOAJ |
| description | Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes, and their development is intricately connected to the disruption of the JAK-STAT signaling pathway, where SOCS proteins play crucial roles. Conditions such as autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis exhibit immune system dysfunctions associated with JAK-STAT signaling dysregulation. Emerging therapeutic strategies utilize JAK-STAT inhibitors and SOCS mimetics to modulate immune responses and alleviate autoimmune manifestations. Although more research and clinical studies are required to assess their effectiveness, safety profiles, and potential for personalized therapeutic approaches in autoimmune conditions, JAK-STAT inhibitors and SOCS mimetics show promise as potential treatment options. This review explores the action, effectiveness, safety profiles, and future prospects of JAK inhibitors and SOCS mimetics as therapeutic agents for psoriasis, autoimmune uveitis, systemic lupus erythematosus, and autoimmune encephalitis. The findings underscore the importance of investigating these targeted therapies to advance treatment options for individuals suffering from autoimmune diseases. |
| first_indexed | 2024-03-11T15:35:11Z |
| format | Article |
| id | doaj.art-83a05da4c8114d09bfed8f8cd1e0ef7b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T15:35:11Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-83a05da4c8114d09bfed8f8cd1e0ef7b2023-10-26T22:17:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12711021271102SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitisRahul Pandey0Marina Bakay1Hakon Hakonarson2Hakon Hakonarson3Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesCenter for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesCenter for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesDepartment of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA, United StatesAutoimmune diseases arise from atypical immune responses that attack self-tissue epitopes, and their development is intricately connected to the disruption of the JAK-STAT signaling pathway, where SOCS proteins play crucial roles. Conditions such as autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis exhibit immune system dysfunctions associated with JAK-STAT signaling dysregulation. Emerging therapeutic strategies utilize JAK-STAT inhibitors and SOCS mimetics to modulate immune responses and alleviate autoimmune manifestations. Although more research and clinical studies are required to assess their effectiveness, safety profiles, and potential for personalized therapeutic approaches in autoimmune conditions, JAK-STAT inhibitors and SOCS mimetics show promise as potential treatment options. This review explores the action, effectiveness, safety profiles, and future prospects of JAK inhibitors and SOCS mimetics as therapeutic agents for psoriasis, autoimmune uveitis, systemic lupus erythematosus, and autoimmune encephalitis. The findings underscore the importance of investigating these targeted therapies to advance treatment options for individuals suffering from autoimmune diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1271102/fullJAK-STATinflammationautoimmunitySOCS (suppressor of cytokine signaling)psoriasisuveitis |
| spellingShingle | Rahul Pandey Marina Bakay Hakon Hakonarson Hakon Hakonarson SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis Frontiers in Immunology JAK-STAT inflammation autoimmunity SOCS (suppressor of cytokine signaling) psoriasis uveitis |
| title | SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis |
| title_full | SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis |
| title_fullStr | SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis |
| title_full_unstemmed | SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis |
| title_short | SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis |
| title_sort | socs jak stat inhibitors and socs mimetics as treatment options for autoimmune uveitis psoriasis lupus and autoimmune encephalitis |
| topic | JAK-STAT inflammation autoimmunity SOCS (suppressor of cytokine signaling) psoriasis uveitis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1271102/full |
| work_keys_str_mv | AT rahulpandey socsjakstatinhibitorsandsocsmimeticsastreatmentoptionsforautoimmuneuveitispsoriasislupusandautoimmuneencephalitis AT marinabakay socsjakstatinhibitorsandsocsmimeticsastreatmentoptionsforautoimmuneuveitispsoriasislupusandautoimmuneencephalitis AT hakonhakonarson socsjakstatinhibitorsandsocsmimeticsastreatmentoptionsforautoimmuneuveitispsoriasislupusandautoimmuneencephalitis AT hakonhakonarson socsjakstatinhibitorsandsocsmimeticsastreatmentoptionsforautoimmuneuveitispsoriasislupusandautoimmuneencephalitis |