Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin

Background: The adenylyl cyclase (AC) pathway, crucial for pulmonary vasodilation, is inhibited by hypoxia. Forskolin (FSK) binds allosterically to AC, stimulating ATP catalysis. As AC6 is the primary AC isoform in the pulmonary artery, selective reactivation of AC6 could provide targeted reinstatem...

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Bibliographic Details
Main Authors: Vikram Bhatia, Saeid Maghsoudi, Martha Hinton, Anjali Y. Bhagirath, Nisha Singh, Appalaraju Jaggupilli, Prashen Chelikani, Shyamala Dakshinamurti
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biology
Subjects:
adenylyl cyclase
cyclic AMP
homology modeling
forskolin
site-directed mutagenesis
Online Access:https://www.mdpi.com/2079-7737/12/4/572

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