Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin
Background: The adenylyl cyclase (AC) pathway, crucial for pulmonary vasodilation, is inhibited by hypoxia. Forskolin (FSK) binds allosterically to AC, stimulating ATP catalysis. As AC6 is the primary AC isoform in the pulmonary artery, selective reactivation of AC6 could provide targeted reinstatem...
| Main Authors: | , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
MDPI AG
2023-04-01
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| 叢編: | Biology |
| 主題: | |
| 在線閱讀: | https://www.mdpi.com/2079-7737/12/4/572 |