Acute-phase reactants
The acute-phase response (APR) is a prominent systemic reaction of the organism to local or systemic disturbances in its homeostasis caused by infection, tissue injury, trauma or surgery, or immunological disorders. The tissue macrophage is most commonly regarded as initiating the APR through direct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of Oral Research and Review |
| Subjects: | |
| Online Access: | http://www.jorr.org/article.asp?issn=2249-4987;year=2016;volume=8;issue=1;spage=32;epage=35;aulast=Grover |
| _version_ | 1818497815064608768 |
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| author | Harpreet Singh Grover Rohit Saini Pearl Bhardwaj Amit Bhardwaj |
| author_facet | Harpreet Singh Grover Rohit Saini Pearl Bhardwaj Amit Bhardwaj |
| author_sort | Harpreet Singh Grover |
| collection | DOAJ |
| description | The acute-phase response (APR) is a prominent systemic reaction of the organism to local or systemic disturbances in its homeostasis caused by infection, tissue injury, trauma or surgery, or immunological disorders. The tissue macrophage is most commonly regarded as initiating the APR through direct stimulation and secretion of various cell communicating factors. Proinflammatory cytokines and mediators are significantly elevated with gingival inflammation and during the destructive phase of periodontitis. Cytokines appear to play a major role in the clinical symptoms and tissue destruction associated with progressing periodontitis. Many of these cytokines are derived from activated macrophages and can act both locally and distally to amplify cytokine production from other cell types. The host responses to periodontal disease and cardiovascular diseases were reflected by an increase in the acute-phase proteins (serum amyloid A and C-reactive protein). |
| first_indexed | 2024-12-10T18:50:05Z |
| format | Article |
| id | doaj.art-83a2fa124b754783ae8a1350c64a677c |
| institution | Directory Open Access Journal |
| issn | 2249-4987 2394-2541 |
| language | English |
| last_indexed | 2024-12-10T18:50:05Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Oral Research and Review |
| spelling | doaj.art-83a2fa124b754783ae8a1350c64a677c2022-12-22T01:37:20ZengWolters Kluwer Medknow PublicationsJournal of Oral Research and Review2249-49872394-25412016-01-0181323510.4103/2249-4987.182491Acute-phase reactantsHarpreet Singh GroverRohit SainiPearl BhardwajAmit BhardwajThe acute-phase response (APR) is a prominent systemic reaction of the organism to local or systemic disturbances in its homeostasis caused by infection, tissue injury, trauma or surgery, or immunological disorders. The tissue macrophage is most commonly regarded as initiating the APR through direct stimulation and secretion of various cell communicating factors. Proinflammatory cytokines and mediators are significantly elevated with gingival inflammation and during the destructive phase of periodontitis. Cytokines appear to play a major role in the clinical symptoms and tissue destruction associated with progressing periodontitis. Many of these cytokines are derived from activated macrophages and can act both locally and distally to amplify cytokine production from other cell types. The host responses to periodontal disease and cardiovascular diseases were reflected by an increase in the acute-phase proteins (serum amyloid A and C-reactive protein).http://www.jorr.org/article.asp?issn=2249-4987;year=2016;volume=8;issue=1;spage=32;epage=35;aulast=GroverAcute-phase proteinsacute-phase responseC-reactive proteincytokineshaptoglobinspentraxinsserum amyloid A |
| spellingShingle | Harpreet Singh Grover Rohit Saini Pearl Bhardwaj Amit Bhardwaj Acute-phase reactants Journal of Oral Research and Review Acute-phase proteins acute-phase response C-reactive protein cytokines haptoglobins pentraxins serum amyloid A |
| title | Acute-phase reactants |
| title_full | Acute-phase reactants |
| title_fullStr | Acute-phase reactants |
| title_full_unstemmed | Acute-phase reactants |
| title_short | Acute-phase reactants |
| title_sort | acute phase reactants |
| topic | Acute-phase proteins acute-phase response C-reactive protein cytokines haptoglobins pentraxins serum amyloid A |
| url | http://www.jorr.org/article.asp?issn=2249-4987;year=2016;volume=8;issue=1;spage=32;epage=35;aulast=Grover |
| work_keys_str_mv | AT harpreetsinghgrover acutephasereactants AT rohitsaini acutephasereactants AT pearlbhardwaj acutephasereactants AT amitbhardwaj acutephasereactants |