Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database
BackgroundThe many studies revealing a connection between serum uric acid (SUA) and dementia have reported conflicting results. This study sought to investigate the relations between SUA and cognitive function in older adults.Materials and methodsThe sample was 2,767 American adults aged ≥60 years f...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1024415/full |
| _version_ | 1811205999541878784 |
|---|---|
| author | Rulin Geng Yu Zhang Miao Liu Shengfeng Deng Jingwen Ding Hongfei Zhong Qiuyun Tu |
| author_facet | Rulin Geng Yu Zhang Miao Liu Shengfeng Deng Jingwen Ding Hongfei Zhong Qiuyun Tu |
| author_sort | Rulin Geng |
| collection | DOAJ |
| description | BackgroundThe many studies revealing a connection between serum uric acid (SUA) and dementia have reported conflicting results. This study sought to investigate the relations between SUA and cognitive function in older adults.Materials and methodsThe sample was 2,767 American adults aged ≥60 years from the National Health and Nutrition Examination Survey 2011–2014. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer’s Disease test, animal fluency test, digit symbol substitution test, and composite z-score. Multivariate linear regression analyses were conducted to estimate the association between SUA and cognitive function.ResultsSUA level and cognitive function were significantly, positively correlated. Age significantly correlated with the association between SUA and cognitive function.ConclusionThese findings support a connection between SUA and cognition, showing a positive link between SUA and cognitive scores among older American adults. We contend that a slight rise in uric acid within the normal range is advantageous for enhanced cognition. To confirm the precise dose-time-response relation, more tests will be needed. |
| first_indexed | 2024-04-12T03:41:08Z |
| format | Article |
| id | doaj.art-83a43c2942f94471a4d4a3acf0de89b2 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T03:41:08Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-83a43c2942f94471a4d4a3acf0de89b22022-12-22T03:49:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-12-011410.3389/fnagi.2022.10244151024415Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES databaseRulin GengYu ZhangMiao LiuShengfeng DengJingwen DingHongfei ZhongQiuyun TuBackgroundThe many studies revealing a connection between serum uric acid (SUA) and dementia have reported conflicting results. This study sought to investigate the relations between SUA and cognitive function in older adults.Materials and methodsThe sample was 2,767 American adults aged ≥60 years from the National Health and Nutrition Examination Survey 2011–2014. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer’s Disease test, animal fluency test, digit symbol substitution test, and composite z-score. Multivariate linear regression analyses were conducted to estimate the association between SUA and cognitive function.ResultsSUA level and cognitive function were significantly, positively correlated. Age significantly correlated with the association between SUA and cognitive function.ConclusionThese findings support a connection between SUA and cognition, showing a positive link between SUA and cognitive scores among older American adults. We contend that a slight rise in uric acid within the normal range is advantageous for enhanced cognition. To confirm the precise dose-time-response relation, more tests will be needed.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1024415/fullcognitive functiondementiaAlzheimer’s diseaseserum uric acidNHANES |
| spellingShingle | Rulin Geng Yu Zhang Miao Liu Shengfeng Deng Jingwen Ding Hongfei Zhong Qiuyun Tu Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database Frontiers in Aging Neuroscience cognitive function dementia Alzheimer’s disease serum uric acid NHANES |
| title | Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database |
| title_full | Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database |
| title_fullStr | Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database |
| title_full_unstemmed | Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database |
| title_short | Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database |
| title_sort | elevated serum uric acid is associated with cognitive improvement in older american adults a large population based analysis of the nhanes database |
| topic | cognitive function dementia Alzheimer’s disease serum uric acid NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1024415/full |
| work_keys_str_mv | AT rulingeng elevatedserumuricacidisassociatedwithcognitiveimprovementinolderamericanadultsalargepopulationbasedanalysisofthenhanesdatabase AT yuzhang elevatedserumuricacidisassociatedwithcognitiveimprovementinolderamericanadultsalargepopulationbasedanalysisofthenhanesdatabase AT miaoliu elevatedserumuricacidisassociatedwithcognitiveimprovementinolderamericanadultsalargepopulationbasedanalysisofthenhanesdatabase AT shengfengdeng elevatedserumuricacidisassociatedwithcognitiveimprovementinolderamericanadultsalargepopulationbasedanalysisofthenhanesdatabase AT jingwending elevatedserumuricacidisassociatedwithcognitiveimprovementinolderamericanadultsalargepopulationbasedanalysisofthenhanesdatabase AT hongfeizhong elevatedserumuricacidisassociatedwithcognitiveimprovementinolderamericanadultsalargepopulationbasedanalysisofthenhanesdatabase AT qiuyuntu elevatedserumuricacidisassociatedwithcognitiveimprovementinolderamericanadultsalargepopulationbasedanalysisofthenhanesdatabase |