Emerging Roles of RNF168 in Tumor Progression
RING finger protein 168 (RNF168) is an E3 ubiquitin ligase with the RING finger domain. It is an important protein contributing to the DNA double-strand damage repair pathway. Recent studies have found that RNF168 is significantly implicated in the occurrence and development of various cancers. Addi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/3/1417 |
| _version_ | 1797623697904762880 |
|---|---|
| author | Tianyuan Xie Hai Qin Zhengdong Yuan Yiwen Zhang Xiaoman Li Lufeng Zheng |
| author_facet | Tianyuan Xie Hai Qin Zhengdong Yuan Yiwen Zhang Xiaoman Li Lufeng Zheng |
| author_sort | Tianyuan Xie |
| collection | DOAJ |
| description | RING finger protein 168 (RNF168) is an E3 ubiquitin ligase with the RING finger domain. It is an important protein contributing to the DNA double-strand damage repair pathway. Recent studies have found that RNF168 is significantly implicated in the occurrence and development of various cancers. Additionally, RNF168 contributes to the drug resistance of tumor cells by enhancing their DNA repair ability or regulating the degradation of target proteins. This paper summarizes and prospects the research progress of the structure and main functions of RNF168, especially its roles and the underlying mechanisms in tumorigenesis. |
| first_indexed | 2024-03-11T09:32:29Z |
| format | Article |
| id | doaj.art-83a65bfcbbc24c32b790f4f1f9a81377 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:32:29Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-83a65bfcbbc24c32b790f4f1f9a813772023-11-16T17:32:11ZengMDPI AGMolecules1420-30492023-02-01283141710.3390/molecules28031417Emerging Roles of RNF168 in Tumor ProgressionTianyuan Xie0Hai Qin1Zhengdong Yuan2Yiwen Zhang3Xiaoman Li4Lufeng Zheng5Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, ChinaDepartment of Clinical Laboratory, Guizhou Provincial Orthopedic Hospital, No. 206, Sixian Street, Baiyun District, Guiyang 550007, ChinaJiangsu Key Laboratory of Carcinogenesis and Intervention, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, ChinaJiangsu Key Laboratory of Carcinogenesis and Intervention, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory of Carcinogenesis and Intervention, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, ChinaRING finger protein 168 (RNF168) is an E3 ubiquitin ligase with the RING finger domain. It is an important protein contributing to the DNA double-strand damage repair pathway. Recent studies have found that RNF168 is significantly implicated in the occurrence and development of various cancers. Additionally, RNF168 contributes to the drug resistance of tumor cells by enhancing their DNA repair ability or regulating the degradation of target proteins. This paper summarizes and prospects the research progress of the structure and main functions of RNF168, especially its roles and the underlying mechanisms in tumorigenesis.https://www.mdpi.com/1420-3049/28/3/1417RING finger protein familyRNF168DNA damage repaircancerE3 ubiquitin ligase |
| spellingShingle | Tianyuan Xie Hai Qin Zhengdong Yuan Yiwen Zhang Xiaoman Li Lufeng Zheng Emerging Roles of RNF168 in Tumor Progression Molecules RING finger protein family RNF168 DNA damage repair cancer E3 ubiquitin ligase |
| title | Emerging Roles of RNF168 in Tumor Progression |
| title_full | Emerging Roles of RNF168 in Tumor Progression |
| title_fullStr | Emerging Roles of RNF168 in Tumor Progression |
| title_full_unstemmed | Emerging Roles of RNF168 in Tumor Progression |
| title_short | Emerging Roles of RNF168 in Tumor Progression |
| title_sort | emerging roles of rnf168 in tumor progression |
| topic | RING finger protein family RNF168 DNA damage repair cancer E3 ubiquitin ligase |
| url | https://www.mdpi.com/1420-3049/28/3/1417 |
| work_keys_str_mv | AT tianyuanxie emergingrolesofrnf168intumorprogression AT haiqin emergingrolesofrnf168intumorprogression AT zhengdongyuan emergingrolesofrnf168intumorprogression AT yiwenzhang emergingrolesofrnf168intumorprogression AT xiaomanli emergingrolesofrnf168intumorprogression AT lufengzheng emergingrolesofrnf168intumorprogression |