Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study
Aim To determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP). Methods Ninety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for...
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PeerJ Inc.
2023-06-01
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| Online Access: | https://peerj.com/articles/15347.pdf |
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| author | Eloi Gine-Serven Maria Martinez-Ramirez Ester Boix-Quintana Eva Davi-Loscos Nicolau Guanyabens Virginia Casado Desiree Muriana Cristina Torres-Rivas M.J. Cuesta Javier Labad |
| author_facet | Eloi Gine-Serven Maria Martinez-Ramirez Ester Boix-Quintana Eva Davi-Loscos Nicolau Guanyabens Virginia Casado Desiree Muriana Cristina Torres-Rivas M.J. Cuesta Javier Labad |
| author_sort | Eloi Gine-Serven |
| collection | DOAJ |
| description | Aim To determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP). Methods Ninety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for one year. Baseline psychiatric evaluation included assessment of prodromal symptoms, positive and negative symptoms, depressive symptoms, stressful life events and cycloid psychosis criteria. Thyroid function (thyroid-stimulating hormone (TSH) and free thyroxin (FT4)) was determined at admission. Partial correlation analysis was conducted to analyse the correlation between levels of TSH/FT4 and symptoms. Logistic regression was performed to explore the association between psychopathological symptoms, 12-month diagnoses and thyroid hormones while adjusting for covariates. Results Patients with prodromal symptomatology showed lower baseline FT4 levels (OR = 0.06; p = 0.018). The duration of untreated psychosis (DUP) was inversely associated with FT4 concentrations (r = − 0.243; p = 0.039). FEP patients with sudden onset of psychotic symptoms (criteria B, cycloid psychosis) showed higher FT4 levels at admission (OR = 10.49; p = 0.040). Patients diagnosed with affective psychotic disorders (BD or MDD) at the 12-month follow-up showed higher FT4 levels at admission than patients diagnosed with nonaffective psychosis (schizophrenia, schizoaffective) (OR = 8.57; p = 0.042). Conclusions Our study suggests that higher free-thyroxine levels are associated with a specific clinical phenotype of FEP patients (fewer prodromal symptoms, shorter DUP duration and sudden onset of psychosis) and with affective psychosis diagnoses at the 12-month follow-up. |
| first_indexed | 2024-03-09T05:17:16Z |
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| language | English |
| last_indexed | 2024-03-09T05:17:16Z |
| publishDate | 2023-06-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-83a8044c5f0940f4b0f8c8dae69e54692023-12-03T12:44:56ZengPeerJ Inc.PeerJ2167-83592023-06-0111e1534710.7717/peerj.15347Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational studyEloi Gine-Serven0Maria Martinez-Ramirez1Ester Boix-Quintana2Eva Davi-Loscos3Nicolau Guanyabens4Virginia Casado5Desiree Muriana6Cristina Torres-Rivas7M.J. Cuesta8Javier Labad9Department of Mental Health, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Mental Health, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Mental Health, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Mental Health, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Neurology, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Neurology, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Neurology, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Mental Health, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainDepartment of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, SpainDepartment of Mental Health, Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, SpainAim To determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP). Methods Ninety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for one year. Baseline psychiatric evaluation included assessment of prodromal symptoms, positive and negative symptoms, depressive symptoms, stressful life events and cycloid psychosis criteria. Thyroid function (thyroid-stimulating hormone (TSH) and free thyroxin (FT4)) was determined at admission. Partial correlation analysis was conducted to analyse the correlation between levels of TSH/FT4 and symptoms. Logistic regression was performed to explore the association between psychopathological symptoms, 12-month diagnoses and thyroid hormones while adjusting for covariates. Results Patients with prodromal symptomatology showed lower baseline FT4 levels (OR = 0.06; p = 0.018). The duration of untreated psychosis (DUP) was inversely associated with FT4 concentrations (r = − 0.243; p = 0.039). FEP patients with sudden onset of psychotic symptoms (criteria B, cycloid psychosis) showed higher FT4 levels at admission (OR = 10.49; p = 0.040). Patients diagnosed with affective psychotic disorders (BD or MDD) at the 12-month follow-up showed higher FT4 levels at admission than patients diagnosed with nonaffective psychosis (schizophrenia, schizoaffective) (OR = 8.57; p = 0.042). Conclusions Our study suggests that higher free-thyroxine levels are associated with a specific clinical phenotype of FEP patients (fewer prodromal symptoms, shorter DUP duration and sudden onset of psychosis) and with affective psychosis diagnoses at the 12-month follow-up.https://peerj.com/articles/15347.pdfBiomarkersFirst episodePsychosisThyroidTSHFT4 |
| spellingShingle | Eloi Gine-Serven Maria Martinez-Ramirez Ester Boix-Quintana Eva Davi-Loscos Nicolau Guanyabens Virginia Casado Desiree Muriana Cristina Torres-Rivas M.J. Cuesta Javier Labad Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study PeerJ Biomarkers First episode Psychosis Thyroid TSH FT4 |
| title | Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study |
| title_full | Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study |
| title_fullStr | Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study |
| title_full_unstemmed | Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study |
| title_short | Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study |
| title_sort | association between free thyroxine levels and clinical phenotype in first episode psychosis a prospective observational study |
| topic | Biomarkers First episode Psychosis Thyroid TSH FT4 |
| url | https://peerj.com/articles/15347.pdf |
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