Functional analysis of the human perivascular subarachnoid space
Abstract The human subarachnoid space harbors the cerebrospinal fluid, which flows within a landscape of blood vessels and trabeculae. Functional implications of subarachnoid space anatomy remain far less understood. This study of 75 patients utilizes a cerebrospinal fluid tracer (gadobutrol) and co...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46329-1 |
| _version_ | 1797273962495868928 |
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| author | Per Kristian Eide Geir Ringstad |
| author_facet | Per Kristian Eide Geir Ringstad |
| author_sort | Per Kristian Eide |
| collection | DOAJ |
| description | Abstract The human subarachnoid space harbors the cerebrospinal fluid, which flows within a landscape of blood vessels and trabeculae. Functional implications of subarachnoid space anatomy remain far less understood. This study of 75 patients utilizes a cerebrospinal fluid tracer (gadobutrol) and consecutive magnetic resonance imaging to investigate features of early (i.e. within 2-3 h after injection) tracer propagation within the subarachnoid space. There is a time-dependent perivascular pattern of enrichment antegrade along the major cerebral artery trunks; the anterior-, middle-, and posterior cerebral arteries. The correlation between time of first enrichment around arteries and early enrichment in nearby cerebral cortex is significant. These observations suggest the existence of a compartmentalized subarachnoid space, where perivascular ensheathment of arteries facilitates antegrade tracer passage towards brain tissue. Periarterial transport is impaired in subjects with reduced intracranial pressure-volume reserve capacity and in idiopathic normal pressure hydrocephalus patients who also show increased perivascular space size. |
| first_indexed | 2024-03-07T14:51:41Z |
| format | Article |
| id | doaj.art-83a86b5bbb394298aa8b9565777a1e69 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:51:41Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-83a86b5bbb394298aa8b9565777a1e692024-03-05T19:40:36ZengNature PortfolioNature Communications2041-17232024-03-0115111410.1038/s41467-024-46329-1Functional analysis of the human perivascular subarachnoid spacePer Kristian Eide0Geir Ringstad1Department of Neurosurgery, Oslo University Hospital - RikshospitaletDepartment of Radiology, Oslo University Hospital- RikshospitaletAbstract The human subarachnoid space harbors the cerebrospinal fluid, which flows within a landscape of blood vessels and trabeculae. Functional implications of subarachnoid space anatomy remain far less understood. This study of 75 patients utilizes a cerebrospinal fluid tracer (gadobutrol) and consecutive magnetic resonance imaging to investigate features of early (i.e. within 2-3 h after injection) tracer propagation within the subarachnoid space. There is a time-dependent perivascular pattern of enrichment antegrade along the major cerebral artery trunks; the anterior-, middle-, and posterior cerebral arteries. The correlation between time of first enrichment around arteries and early enrichment in nearby cerebral cortex is significant. These observations suggest the existence of a compartmentalized subarachnoid space, where perivascular ensheathment of arteries facilitates antegrade tracer passage towards brain tissue. Periarterial transport is impaired in subjects with reduced intracranial pressure-volume reserve capacity and in idiopathic normal pressure hydrocephalus patients who also show increased perivascular space size.https://doi.org/10.1038/s41467-024-46329-1 |
| spellingShingle | Per Kristian Eide Geir Ringstad Functional analysis of the human perivascular subarachnoid space Nature Communications |
| title | Functional analysis of the human perivascular subarachnoid space |
| title_full | Functional analysis of the human perivascular subarachnoid space |
| title_fullStr | Functional analysis of the human perivascular subarachnoid space |
| title_full_unstemmed | Functional analysis of the human perivascular subarachnoid space |
| title_short | Functional analysis of the human perivascular subarachnoid space |
| title_sort | functional analysis of the human perivascular subarachnoid space |
| url | https://doi.org/10.1038/s41467-024-46329-1 |
| work_keys_str_mv | AT perkristianeide functionalanalysisofthehumanperivascularsubarachnoidspace AT geirringstad functionalanalysisofthehumanperivascularsubarachnoidspace |