Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides
Layered double hydroxides (LDHs) are one of the very important nano-carriers for drug delivery, due to their many advantageous features, such as the ease and low-cost of preparation, low cytotoxicity, good biocompatibility, protection for the intercalated drugs, and the capacity to facilitate the up...
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| Format: | Article |
| Language: | English |
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Croatian Chemical Society
2015-12-01
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| Series: | Croatica Chemica Acta |
| Online Access: | http://hrcak.srce.hr/file/223184 |
| _version_ | 1819169379033546752 |
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| author | E. Kuzmann V. K. Garg A. C. de Oliveira L. Herojit Singh S. S. Pati E. M. Guimaraes Tatiane O. dos Santos M. Ádok-Sipiczki P. Sipos I. Pálinkó |
| author_facet | E. Kuzmann V. K. Garg A. C. de Oliveira L. Herojit Singh S. S. Pati E. M. Guimaraes Tatiane O. dos Santos M. Ádok-Sipiczki P. Sipos I. Pálinkó |
| author_sort | E. Kuzmann |
| collection | DOAJ |
| description | Layered double hydroxides (LDHs) are one of the very important nano-carriers for drug delivery, due to their many advantageous features, such as the ease and low-cost of preparation, low cytotoxicity, good biocompatibility, protection for the intercalated drugs, and the capacity to facilitate the uptake of the loaded drug in the cells. In our previous studies, Mössbauer spectroscopy was applied to monitor structural changes occurring during the incorporation of Fe(III) in MgFe- and CaFe-LDHs, and the intercalation of various organic compounds in anionic form. Recently, we have successfully elaborated a protocol for the intercalation and release of indol-2-carboxylate and L-cysteinate in CaFe-LDH. The corresponding structural changes in the LDH samples were studied by XRD, HR-TEM and <sup>57</sup>Fe Mössbauer spectroscopy. The Mössbauer spectra reflected small but significant changes upon both the intercalation and the release of drugs. The changes in the basal distances could be followed by XRD measurements, and HR-TEM images made these changes visible. |
| first_indexed | 2024-12-22T19:18:33Z |
| format | Article |
| id | doaj.art-83a944ad4254454fac312db2c8564281 |
| institution | Directory Open Access Journal |
| issn | 0011-1643 1334-417X |
| language | English |
| last_indexed | 2024-12-22T19:18:33Z |
| publishDate | 2015-12-01 |
| publisher | Croatian Chemical Society |
| record_format | Article |
| series | Croatica Chemica Acta |
| spelling | doaj.art-83a944ad4254454fac312db2c85642812022-12-21T18:15:26ZengCroatian Chemical SocietyCroatica Chemica Acta0011-16431334-417X2015-12-0188436937610.5562/cca2683151712Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double HydroxidesE. Kuzmann0V. K. Garg1A. C. de Oliveira2L. Herojit Singh3S. S. Pati4E. M. Guimaraes5Tatiane O. dos Santos6M. Ádok-Sipiczki7P. Sipos8I. Pálinkó9Institute of Chemistry, Eötvös Loránd University, Pázmány P. s. 1/A, Budapest, H-1117, HungaryInstitute of Physics, University of Brasília, Brasília DF, BrazilInstitute of Physics, University of Brasília, Brasília DF, BrazilInstitute of Physics, University of Brasília, Brasília DF, BrazilInstitute of Physics, University of Brasília, Brasília DF, BrazilInstitute of Geosciences, University of Brasília, Brasília DF, BrazilInstitute of Physics, Federal University of Goiás, Goiânia, BrazilDepartment of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720 HungaryDepartment of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720 HungaryDepartment of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720 HungaryLayered double hydroxides (LDHs) are one of the very important nano-carriers for drug delivery, due to their many advantageous features, such as the ease and low-cost of preparation, low cytotoxicity, good biocompatibility, protection for the intercalated drugs, and the capacity to facilitate the uptake of the loaded drug in the cells. In our previous studies, Mössbauer spectroscopy was applied to monitor structural changes occurring during the incorporation of Fe(III) in MgFe- and CaFe-LDHs, and the intercalation of various organic compounds in anionic form. Recently, we have successfully elaborated a protocol for the intercalation and release of indol-2-carboxylate and L-cysteinate in CaFe-LDH. The corresponding structural changes in the LDH samples were studied by XRD, HR-TEM and <sup>57</sup>Fe Mössbauer spectroscopy. The Mössbauer spectra reflected small but significant changes upon both the intercalation and the release of drugs. The changes in the basal distances could be followed by XRD measurements, and HR-TEM images made these changes visible.http://hrcak.srce.hr/file/223184 |
| spellingShingle | E. Kuzmann V. K. Garg A. C. de Oliveira L. Herojit Singh S. S. Pati E. M. Guimaraes Tatiane O. dos Santos M. Ádok-Sipiczki P. Sipos I. Pálinkó Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides Croatica Chemica Acta |
| title | Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides |
| title_full | Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides |
| title_fullStr | Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides |
| title_full_unstemmed | Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides |
| title_short | Mössbauer, XRD and TEM Study on the Intercalation and the Release of Drugs in/from Layered Double Hydroxides |
| title_sort | mossbauer xrd and tem study on the intercalation and the release of drugs in from layered double hydroxides |
| url | http://hrcak.srce.hr/file/223184 |
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