Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates.

Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates.

The ATR-Chk1 DNA damage checkpoint pathway is a critical regulator of the cellular response to DNA damage and replication stress in human cells. The variety of environmental, chemotherapeutic, and carcinogenic agents that activate this signal transduction pathway do so primarily through the formatio...

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Bibliographic Details
Main Authors: Seçil Yilmaz, Aziz Sancar, Michael G Kemp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3146532?pdf=render

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