Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools
The present study aimed to assess metabolites heterogeneity among four major <i>Cinnamomum</i> species, including true cinnamon (<i>Cinnamomum verum</i>) and less explored species (<i>C. cassia</i>, <i>C. iners</i>, and <i>C. tamala</i>). U...
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/9/2935 |
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| author | Mohamed A. Farag Eman M. Kabbash Ahmed Mediani Stefanie Döll Tuba Esatbeyoglu Sherif M. Afifi |
| author_facet | Mohamed A. Farag Eman M. Kabbash Ahmed Mediani Stefanie Döll Tuba Esatbeyoglu Sherif M. Afifi |
| author_sort | Mohamed A. Farag |
| collection | DOAJ |
| description | The present study aimed to assess metabolites heterogeneity among four major <i>Cinnamomum</i> species, including true cinnamon (<i>Cinnamomum verum</i>) and less explored species (<i>C. cassia</i>, <i>C. iners</i>, and <i>C. tamala</i>). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in <i>C. tamala,</i> along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in <i>C. verum</i> versus procyandins, dihydro-coumaroylglycosides, and coumarin in <i>C. cassia</i>. A total of 51 primary metabolites were detected using GC-MS analysis encompassing different classes, <i>viz</i>. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in <i>C. tamala</i>, erythritol in <i>C. iners</i>, and glucose and fructose in <i>C. verum</i> from Malaysia were major metabolites contributing to the discrimination among species. |
| first_indexed | 2024-03-10T03:53:45Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:53:45Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-83ada0c772344b5bb6d80bbad6213f4d2023-11-23T08:51:48ZengMDPI AGMolecules1420-30492022-05-01279293510.3390/molecules27092935Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric ToolsMohamed A. Farag0Eman M. Kabbash1Ahmed Mediani2Stefanie Döll3Tuba Esatbeyoglu4Sherif M. Afifi5Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St., Cairo 11562, EgyptPhytochemistry Department, National Organization for Drug Control and Research, Giza 12622, EgyptInstitute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, MalaysiaGerman Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Puschstraße 4, 04103 Leipzig, GermanyDepartment of Food Development and Food Quality, Institute of Food Science and Human Nutrition, Gottfried Wilhelm Leibniz University Hannover, Am KleinenFelde 30, 30167 Hannover, GermanyPharmacognosy Department, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, EgyptThe present study aimed to assess metabolites heterogeneity among four major <i>Cinnamomum</i> species, including true cinnamon (<i>Cinnamomum verum</i>) and less explored species (<i>C. cassia</i>, <i>C. iners</i>, and <i>C. tamala</i>). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in <i>C. tamala,</i> along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in <i>C. verum</i> versus procyandins, dihydro-coumaroylglycosides, and coumarin in <i>C. cassia</i>. A total of 51 primary metabolites were detected using GC-MS analysis encompassing different classes, <i>viz</i>. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in <i>C. tamala</i>, erythritol in <i>C. iners</i>, and glucose and fructose in <i>C. verum</i> from Malaysia were major metabolites contributing to the discrimination among species.https://www.mdpi.com/1420-3049/27/9/2935chemometrics<i>Cinnamomum</i>erythritolmetabolomicsproanthocyanidin |
| spellingShingle | Mohamed A. Farag Eman M. Kabbash Ahmed Mediani Stefanie Döll Tuba Esatbeyoglu Sherif M. Afifi Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools Molecules chemometrics <i>Cinnamomum</i> erythritol metabolomics proanthocyanidin |
| title | Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools |
| title_full | Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools |
| title_fullStr | Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools |
| title_full_unstemmed | Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools |
| title_short | Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools |
| title_sort | comparative metabolite fingerprinting of four different cinnamon species analyzed via uplc ms and gc ms and chemometric tools |
| topic | chemometrics <i>Cinnamomum</i> erythritol metabolomics proanthocyanidin |
| url | https://www.mdpi.com/1420-3049/27/9/2935 |
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