Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis
Heart transplant (HTx) still represents the most effective therapy for end-stage heart failure, with a median survival time of 10 years. The transplanted heart shows peculiar physiology due to the profound alterations induced by the operation, which inevitably influences several echocardiographic pa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.969270/full |
| _version_ | 1811256891546796032 |
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| author | Carlotta Sciaccaluga Chiara Fusi Federico Landra Maria Barilli Matteo Lisi Matteo Lisi Giulia Elena Mandoli Flavio D’Ascenzi Marta Focardi Serafina Valente Matteo Cameli |
| author_facet | Carlotta Sciaccaluga Chiara Fusi Federico Landra Maria Barilli Matteo Lisi Matteo Lisi Giulia Elena Mandoli Flavio D’Ascenzi Marta Focardi Serafina Valente Matteo Cameli |
| author_sort | Carlotta Sciaccaluga |
| collection | DOAJ |
| description | Heart transplant (HTx) still represents the most effective therapy for end-stage heart failure, with a median survival time of 10 years. The transplanted heart shows peculiar physiology due to the profound alterations induced by the operation, which inevitably influences several echocardiographic parameters assessed during these patients’ follow-ups. With these premises, the diastolic function is one of the main aspects to take into consideration. The left atrium (LA) plays a key role in this matter, and that same chamber is significantly impaired with the transplant, with different degrees of altered function based on the surgical technique. Therefore, the traditional echocardiographic evaluation of diastolic function applied to the general population might not properly reflect the physiology of the graft. This review attempts to provide current evidence on diastolic function in HTx starting from defining its different physiology and how the standard echocardiographic parameters might be affected to its prognostic role. Furthermore, based on the experience of our center and the available evidence, we proposed an algorithm that might help clinicians distinguish from actual diastolic dysfunction from a normal diastolic pattern in HTx population. |
| first_indexed | 2024-04-12T17:48:09Z |
| format | Article |
| id | doaj.art-83afc78c70ae4fad93cc7ee589f81ee4 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T17:48:09Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-83afc78c70ae4fad93cc7ee589f81ee42022-12-22T03:22:34ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-10-01910.3389/fcvm.2022.969270969270Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosisCarlotta Sciaccaluga0Chiara Fusi1Federico Landra2Maria Barilli3Matteo Lisi4Matteo Lisi5Giulia Elena Mandoli6Flavio D’Ascenzi7Marta Focardi8Serafina Valente9Matteo Cameli10Division of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Cardiovascular Diseases - Azienda Unità Sanitaria Locale (AUSL) Romagna, “Santa Maria delle Croci” Hospital, Ravenna, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, ItalyHeart transplant (HTx) still represents the most effective therapy for end-stage heart failure, with a median survival time of 10 years. The transplanted heart shows peculiar physiology due to the profound alterations induced by the operation, which inevitably influences several echocardiographic parameters assessed during these patients’ follow-ups. With these premises, the diastolic function is one of the main aspects to take into consideration. The left atrium (LA) plays a key role in this matter, and that same chamber is significantly impaired with the transplant, with different degrees of altered function based on the surgical technique. Therefore, the traditional echocardiographic evaluation of diastolic function applied to the general population might not properly reflect the physiology of the graft. This review attempts to provide current evidence on diastolic function in HTx starting from defining its different physiology and how the standard echocardiographic parameters might be affected to its prognostic role. Furthermore, based on the experience of our center and the available evidence, we proposed an algorithm that might help clinicians distinguish from actual diastolic dysfunction from a normal diastolic pattern in HTx population.https://www.frontiersin.org/articles/10.3389/fcvm.2022.969270/fulldiastolic functionheart transplantechocardiographyprognosisphysiology |
| spellingShingle | Carlotta Sciaccaluga Chiara Fusi Federico Landra Maria Barilli Matteo Lisi Matteo Lisi Giulia Elena Mandoli Flavio D’Ascenzi Marta Focardi Serafina Valente Matteo Cameli Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis Frontiers in Cardiovascular Medicine diastolic function heart transplant echocardiography prognosis physiology |
| title | Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis |
| title_full | Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis |
| title_fullStr | Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis |
| title_full_unstemmed | Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis |
| title_short | Diastolic function in heart transplant: From physiology to echocardiographic assessment and prognosis |
| title_sort | diastolic function in heart transplant from physiology to echocardiographic assessment and prognosis |
| topic | diastolic function heart transplant echocardiography prognosis physiology |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.969270/full |
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