Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?
Heart failure (HF) is a plague of the aging population in industrialized countries that continues to cause many deaths despite intensive research into more effective treatments. Although the therapeutic arsenal to face heart failure has been expanding, the relatively short life expectancy of HF pati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/1/30 |
| _version_ | 1797498949034049536 |
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| author | Jérôme Piquereau Solène E. Boitard Renée Ventura-Clapier Mathias Mericskay |
| author_facet | Jérôme Piquereau Solène E. Boitard Renée Ventura-Clapier Mathias Mericskay |
| author_sort | Jérôme Piquereau |
| collection | DOAJ |
| description | Heart failure (HF) is a plague of the aging population in industrialized countries that continues to cause many deaths despite intensive research into more effective treatments. Although the therapeutic arsenal to face heart failure has been expanding, the relatively short life expectancy of HF patients is pushing towards novel therapeutic strategies. Heart failure is associated with drastic metabolic disorders, including severe myocardial mitochondrial dysfunction and systemic nutrient deprivation secondary to severe cardiac dysfunction. To date, no effective therapy has been developed to restore the cardiac energy metabolism of the failing myocardium, mainly due to the metabolic complexity and intertwining of the involved processes. Recent years have witnessed a growing scientific interest in natural molecules that play a pivotal role in energy metabolism with promising therapeutic effects against heart failure. Among these molecules, B vitamins are a class of water soluble vitamins that are directly involved in energy metabolism and are of particular interest since they are intimately linked to energy metabolism and HF patients are often B vitamin deficient. This review aims at assessing the value of B vitamin supplementation in the treatment of heart failure. |
| first_indexed | 2024-03-10T03:40:35Z |
| format | Article |
| id | doaj.art-83b1ab95ed604ae19bafee657255a681 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:40:35Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-83b1ab95ed604ae19bafee657255a6812023-11-23T11:33:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012313010.3390/ijms23010030Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?Jérôme Piquereau0Solène E. Boitard1Renée Ventura-Clapier2Mathias Mericskay3UMR-S 1180, Inserm Unit of Signaling and Cardiovascular Pathophysiology, Faculty of Pharmacy, Université Paris-Saclay, 92296 Chatenay-Malabry, FranceUMR-S 1180, Inserm Unit of Signaling and Cardiovascular Pathophysiology, Faculty of Pharmacy, Université Paris-Saclay, 92296 Chatenay-Malabry, FranceUMR-S 1180, Inserm Unit of Signaling and Cardiovascular Pathophysiology, Faculty of Pharmacy, Université Paris-Saclay, 92296 Chatenay-Malabry, FranceUMR-S 1180, Inserm Unit of Signaling and Cardiovascular Pathophysiology, Faculty of Pharmacy, Université Paris-Saclay, 92296 Chatenay-Malabry, FranceHeart failure (HF) is a plague of the aging population in industrialized countries that continues to cause many deaths despite intensive research into more effective treatments. Although the therapeutic arsenal to face heart failure has been expanding, the relatively short life expectancy of HF patients is pushing towards novel therapeutic strategies. Heart failure is associated with drastic metabolic disorders, including severe myocardial mitochondrial dysfunction and systemic nutrient deprivation secondary to severe cardiac dysfunction. To date, no effective therapy has been developed to restore the cardiac energy metabolism of the failing myocardium, mainly due to the metabolic complexity and intertwining of the involved processes. Recent years have witnessed a growing scientific interest in natural molecules that play a pivotal role in energy metabolism with promising therapeutic effects against heart failure. Among these molecules, B vitamins are a class of water soluble vitamins that are directly involved in energy metabolism and are of particular interest since they are intimately linked to energy metabolism and HF patients are often B vitamin deficient. This review aims at assessing the value of B vitamin supplementation in the treatment of heart failure.https://www.mdpi.com/1422-0067/23/1/30heart failureenergy metabolismmitochondriaB vitaminsthiaminriboflavin |
| spellingShingle | Jérôme Piquereau Solène E. Boitard Renée Ventura-Clapier Mathias Mericskay Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? International Journal of Molecular Sciences heart failure energy metabolism mitochondria B vitamins thiamin riboflavin |
| title | Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? |
| title_full | Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? |
| title_fullStr | Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? |
| title_full_unstemmed | Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? |
| title_short | Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? |
| title_sort | metabolic therapy of heart failure is there a future for b vitamins |
| topic | heart failure energy metabolism mitochondria B vitamins thiamin riboflavin |
| url | https://www.mdpi.com/1422-0067/23/1/30 |
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