Sodium tanshinone IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and AKT/MAPKs signaling in human umbilical vascular endothelial cells

Sodium tanshinone IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and AKT/MAPKs signaling in human umbilical vascular endothelial cells

Homocysteine (Hcy) is one of the independent risk factors of cardiovascular disease. Sodium tanshinone IIA sulfonate (STS) is a hydrophilic derivate of tanshinone IIA which is the main active constitute of Chinese Materia Medica Salviae Miltiorrhizae Radix et Rhizoma, and exhibits multiple pharmacol...

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Bibliographic Details
Main Authors: Zhong-Yan Zhou, Wen-Ting Shi, Jing Zhang, Wai-Rong Zhao, Ying Xiao, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Yu Wang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Vascular endothelial dysfunction
Oxidative stress
Mitochondrial dysfunction
Nicotinamide
Methylnicotinamide
Hyperhomocysteinemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222015268

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http://www.sciencedirect.com/science/article/pii/S0753332222015268

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