Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts
Hemerocallis citrina Baroni [Asphodelaceae], which is traditional herbal medicine, has been widely used for treating depressive disorders in Eastern-Asia countries. However, the active compounds and corresponding mechanism of anti-depression are not yet completely clarified. In this study, the anti-...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.967670/full |
| _version_ | 1811285691278032896 |
|---|---|
| author | Jinghong Liu Jinghong Liu Tian Ye Shuaiyong Yang Xiaohong Zhong Wei He Mengtao Xu Jinpeng Fang Miao Deng Ning Xu Jianguo Zeng Jianguo Zeng Zhixing Qing Zhixing Qing |
| author_facet | Jinghong Liu Jinghong Liu Tian Ye Shuaiyong Yang Xiaohong Zhong Wei He Mengtao Xu Jinpeng Fang Miao Deng Ning Xu Jianguo Zeng Jianguo Zeng Zhixing Qing Zhixing Qing |
| author_sort | Jinghong Liu |
| collection | DOAJ |
| description | Hemerocallis citrina Baroni [Asphodelaceae], which is traditional herbal medicine, has been widely used for treating depressive disorders in Eastern-Asia countries. However, the active compounds and corresponding mechanism of anti-depression are not yet completely clarified. In this study, the anti-depressive activities of six H. citrina extracts were primarily evaluated. The results showed that the water extract of H. citrina flowers (HCW) displays significant anti-depressive activity. A total of 32 metabolites were identified from HCW by high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) and nuclear magnetic resonance (NMR). And then, the anti-depressive activity of the high-level compound (rutin) in HCW was also estimated. The results indicated that rutin displayed significant anti-depressive activity and was one of the main active ingredients. Finally, the anti-depressive mechanisms of HCW and rutin were investigated based on the intestinal microorganisms. The results showed that HCW and rutin increase the diversity and richness of the intestinal flora and regulate the specific intestinal microorganisms such as Bacteroides and Desulfovibrio genera in depressed mice. This work marks the first comprehensive study of the active components, anti-depressive activities and corresponding mechanisms of different H. citrina extracts, which provide a potential possibility for developing new antidepressants. |
| first_indexed | 2024-04-13T02:48:41Z |
| format | Article |
| id | doaj.art-83b47c00e23c4e41933e5d67841b6c41 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T02:48:41Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-83b47c00e23c4e41933e5d67841b6c412022-12-22T03:05:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.967670967670Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extractsJinghong Liu0Jinghong Liu1Tian Ye2Shuaiyong Yang3Xiaohong Zhong4Wei He5Mengtao Xu6Jinpeng Fang7Miao Deng8Ning Xu9Jianguo Zeng10Jianguo Zeng11Zhixing Qing12Zhixing Qing13College of Horticulture, Hunan Agricultural University, Changsha, ChinaGreen Melody Bioengineering Group Company Limited, Changsha, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha, ChinaGreen Melody Bioengineering Group Company Limited, Changsha, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, ChinaDatong Daylily Industrial Development Research Institute, Datong, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, ChinaDatong Daylily Industrial Development Research Institute, Datong, ChinaHemerocallis citrina Baroni [Asphodelaceae], which is traditional herbal medicine, has been widely used for treating depressive disorders in Eastern-Asia countries. However, the active compounds and corresponding mechanism of anti-depression are not yet completely clarified. In this study, the anti-depressive activities of six H. citrina extracts were primarily evaluated. The results showed that the water extract of H. citrina flowers (HCW) displays significant anti-depressive activity. A total of 32 metabolites were identified from HCW by high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) and nuclear magnetic resonance (NMR). And then, the anti-depressive activity of the high-level compound (rutin) in HCW was also estimated. The results indicated that rutin displayed significant anti-depressive activity and was one of the main active ingredients. Finally, the anti-depressive mechanisms of HCW and rutin were investigated based on the intestinal microorganisms. The results showed that HCW and rutin increase the diversity and richness of the intestinal flora and regulate the specific intestinal microorganisms such as Bacteroides and Desulfovibrio genera in depressed mice. This work marks the first comprehensive study of the active components, anti-depressive activities and corresponding mechanisms of different H. citrina extracts, which provide a potential possibility for developing new antidepressants.https://www.frontiersin.org/articles/10.3389/fphar.2022.967670/fullchemical constituentsHPLC-Q-TOF-MSCUMS micehemerocallis citrina baroni [asphodelaceae]antidepressant-like effectintestinal flora |
| spellingShingle | Jinghong Liu Jinghong Liu Tian Ye Shuaiyong Yang Xiaohong Zhong Wei He Mengtao Xu Jinpeng Fang Miao Deng Ning Xu Jianguo Zeng Jianguo Zeng Zhixing Qing Zhixing Qing Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts Frontiers in Pharmacology chemical constituents HPLC-Q-TOF-MS CUMS mice hemerocallis citrina baroni [asphodelaceae] antidepressant-like effect intestinal flora |
| title | Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts |
| title_full | Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts |
| title_fullStr | Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts |
| title_full_unstemmed | Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts |
| title_short | Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts |
| title_sort | antidepressant like activity active components and related mechanism of hemerocallis citrina baroni extracts |
| topic | chemical constituents HPLC-Q-TOF-MS CUMS mice hemerocallis citrina baroni [asphodelaceae] antidepressant-like effect intestinal flora |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.967670/full |
| work_keys_str_mv | AT jinghongliu antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT jinghongliu antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT tianye antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT shuaiyongyang antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT xiaohongzhong antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT weihe antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT mengtaoxu antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT jinpengfang antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT miaodeng antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT ningxu antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT jianguozeng antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT jianguozeng antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT zhixingqing antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts AT zhixingqing antidepressantlikeactivityactivecomponentsandrelatedmechanismofhemerocalliscitrinabaroniextracts |