Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial
Abstract Background Conventional pharmacologic therapies aim to reduce fluid overload in advanced heart failure (HF) represented by intravenous (IV) loop diuretics (LDs) have sometimes not so efficacious and been reported to have side effects such as unpredictable removal of water and sodium and ele...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-019-1208-y |
| _version_ | 1818523387358609408 |
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| author | Ying Yang Chao Shen Jiangting Lu Fen Xu Jinshan Tong Jiangfen Jiang Guosheng Fu |
| author_facet | Ying Yang Chao Shen Jiangting Lu Fen Xu Jinshan Tong Jiangfen Jiang Guosheng Fu |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | Abstract Background Conventional pharmacologic therapies aim to reduce fluid overload in advanced heart failure (HF) represented by intravenous (IV) loop diuretics (LDs) have sometimes not so efficacious and been reported to have side effects such as unpredictable removal of water and sodium and electrolyte disturbance. It is not certain whether early ultrafiltration (UF) is effective than LDs in relieving edema. Given the weakness of evidence for early UF in patients with fluid overload, recommendations of UF in guidelines is considered as second-line therapy only for patients with refractory congestion, who failed to respond to LD-based strategies. Methods The early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF) trial is an open-label, registry-based, prospective study, recruiting patients with severe acute decompensated HF who are hospitalized for HF worsening due to overt fluid overload 24 h from hospital admission. Forty patients will be enrolled to two treatment groups (n = 20 for each group). The primary outcomes are the changes of weight loss and dyspnea severity score after treatment, as well as the occurrence of clinically overt major bleeding. Discussion EUC-CHF trial was primarily designed to evaluate the efficacy and safety of early UF in patients with acute decompensated HF to reduce volume overload and improve clinical outcome. The trial aims to determine if early UF in acute HF is superior to IV LDs in clinical parameter improvement without adverse events and prevents rehospitalization up to 30 days. Also the trial is expected to establish a scoring system based on Chinese population to guide early UF treatment in appropriate patients. EUC-CHF is one of the first controlled trials tailored to determine the benefit of UF with 24 h from hospital admission. Trial registration www.chictr.org.cn, ChiCTR1800019556. Registered on 18 November 2018. |
| first_indexed | 2024-12-11T05:44:19Z |
| format | Article |
| id | doaj.art-83b534a99fb24f489c19ebe843838302 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-11T05:44:19Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-83b534a99fb24f489c19ebe8438383022022-12-22T01:19:02ZengBMCBMC Cardiovascular Disorders1471-22612019-11-011911910.1186/s12872-019-1208-yEarly continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trialYing Yang0Chao Shen1Jiangting Lu2Fen Xu3Jinshan Tong4Jiangfen Jiang5Guosheng Fu6Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityDepartment of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityAbstract Background Conventional pharmacologic therapies aim to reduce fluid overload in advanced heart failure (HF) represented by intravenous (IV) loop diuretics (LDs) have sometimes not so efficacious and been reported to have side effects such as unpredictable removal of water and sodium and electrolyte disturbance. It is not certain whether early ultrafiltration (UF) is effective than LDs in relieving edema. Given the weakness of evidence for early UF in patients with fluid overload, recommendations of UF in guidelines is considered as second-line therapy only for patients with refractory congestion, who failed to respond to LD-based strategies. Methods The early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF) trial is an open-label, registry-based, prospective study, recruiting patients with severe acute decompensated HF who are hospitalized for HF worsening due to overt fluid overload 24 h from hospital admission. Forty patients will be enrolled to two treatment groups (n = 20 for each group). The primary outcomes are the changes of weight loss and dyspnea severity score after treatment, as well as the occurrence of clinically overt major bleeding. Discussion EUC-CHF trial was primarily designed to evaluate the efficacy and safety of early UF in patients with acute decompensated HF to reduce volume overload and improve clinical outcome. The trial aims to determine if early UF in acute HF is superior to IV LDs in clinical parameter improvement without adverse events and prevents rehospitalization up to 30 days. Also the trial is expected to establish a scoring system based on Chinese population to guide early UF treatment in appropriate patients. EUC-CHF is one of the first controlled trials tailored to determine the benefit of UF with 24 h from hospital admission. Trial registration www.chictr.org.cn, ChiCTR1800019556. Registered on 18 November 2018.http://link.springer.com/article/10.1186/s12872-019-1208-yEarly ultrafiltrationHeart failureFluid overloadLoop diureticsContinuous renal replacement therapyInflammatory cytokines |
| spellingShingle | Ying Yang Chao Shen Jiangting Lu Fen Xu Jinshan Tong Jiangfen Jiang Guosheng Fu Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial BMC Cardiovascular Disorders Early ultrafiltration Heart failure Fluid overload Loop diuretics Continuous renal replacement therapy Inflammatory cytokines |
| title | Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial |
| title_full | Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial |
| title_fullStr | Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial |
| title_full_unstemmed | Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial |
| title_short | Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial |
| title_sort | early continuous ultrafiltration in chinese patients with congestive heart failure euc chf study protocol for an open label registry based prospective clinical trial |
| topic | Early ultrafiltration Heart failure Fluid overload Loop diuretics Continuous renal replacement therapy Inflammatory cytokines |
| url | http://link.springer.com/article/10.1186/s12872-019-1208-y |
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