Transcriptional and Post-Transcriptional Regulation of Autophagy
Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through...
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MDPI AG
2022-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/441 |
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| author | Qiuqin Ma Shihui Long Zhending Gan Gianluca Tettamanti Kang Li Ling Tian |
| author_facet | Qiuqin Ma Shihui Long Zhending Gan Gianluca Tettamanti Kang Li Ling Tian |
| author_sort | Qiuqin Ma |
| collection | DOAJ |
| description | Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. In general, autophagy is synergistically governed at the RNA and protein levels. The upstream transcription factors trigger or inhibit the expression of autophagy- or lysosome-related genes to facilitate or reduce autophagy. Moreover, a significant number of non-coding RNAs (microRNA, circRNA, and lncRNA) are reported to participate in autophagy regulation. Finally, post-transcriptional modifications, such as RNA methylation, play a key role in controlling autophagy occurrence. In this review, we summarize the progress on autophagy research regarding transcriptional regulation, which will provide the foundations and directions for future studies on this self-eating process. |
| first_indexed | 2024-03-10T00:03:21Z |
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| id | doaj.art-83b6a9f50db54dcc966acd502868abe0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:03:21Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-83b6a9f50db54dcc966acd502868abe02023-11-23T16:11:53ZengMDPI AGCells2073-44092022-01-0111344110.3390/cells11030441Transcriptional and Post-Transcriptional Regulation of AutophagyQiuqin Ma0Shihui Long1Zhending Gan2Gianluca Tettamanti3Kang Li4Ling Tian5Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, ChinaGuangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou 510631, ChinaGuangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, ChinaDepartment of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, ItalyGuangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, ChinaGuangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, ChinaAutophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. In general, autophagy is synergistically governed at the RNA and protein levels. The upstream transcription factors trigger or inhibit the expression of autophagy- or lysosome-related genes to facilitate or reduce autophagy. Moreover, a significant number of non-coding RNAs (microRNA, circRNA, and lncRNA) are reported to participate in autophagy regulation. Finally, post-transcriptional modifications, such as RNA methylation, play a key role in controlling autophagy occurrence. In this review, we summarize the progress on autophagy research regarding transcriptional regulation, which will provide the foundations and directions for future studies on this self-eating process.https://www.mdpi.com/2073-4409/11/3/441autophagyregulatory mechanismstranscriptionncRNARNA methylation |
| spellingShingle | Qiuqin Ma Shihui Long Zhending Gan Gianluca Tettamanti Kang Li Ling Tian Transcriptional and Post-Transcriptional Regulation of Autophagy Cells autophagy regulatory mechanisms transcription ncRNA RNA methylation |
| title | Transcriptional and Post-Transcriptional Regulation of Autophagy |
| title_full | Transcriptional and Post-Transcriptional Regulation of Autophagy |
| title_fullStr | Transcriptional and Post-Transcriptional Regulation of Autophagy |
| title_full_unstemmed | Transcriptional and Post-Transcriptional Regulation of Autophagy |
| title_short | Transcriptional and Post-Transcriptional Regulation of Autophagy |
| title_sort | transcriptional and post transcriptional regulation of autophagy |
| topic | autophagy regulatory mechanisms transcription ncRNA RNA methylation |
| url | https://www.mdpi.com/2073-4409/11/3/441 |
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