Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice
The craniofacial skeleton is a complex and unique structure. The perturbation of its development can lead to craniofacial dysmorphology and associated morbidities. Our ability to prevent or mitigate craniofacial skeletal anomalies is at least partly dependent on our understanding of the unique physi...
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| Format: | Article |
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Frontiers Media S.A.
2017-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00697/full |
| _version_ | 1818179826139267072 |
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| author | Xiaoxi Wei Xiaoxi Wei Neil Thomas Nan E. Hatch Min Hu Fei Liu |
| author_facet | Xiaoxi Wei Xiaoxi Wei Neil Thomas Nan E. Hatch Min Hu Fei Liu |
| author_sort | Xiaoxi Wei |
| collection | DOAJ |
| description | The craniofacial skeleton is a complex and unique structure. The perturbation of its development can lead to craniofacial dysmorphology and associated morbidities. Our ability to prevent or mitigate craniofacial skeletal anomalies is at least partly dependent on our understanding of the unique physiological development of the craniofacial skeleton. Mouse models are critical tools for the study of craniofacial developmental abnormalities. However, there is a lack of detailed normative data of mouse craniofacial skeletal development in the literature. In this report, we employed high-resolution micro-computed tomography (μCT) in combination with morphometric measurements to analyze the postnatal craniofacial skeletal development from day 7 (P7) through day 390 (P390) of female C57BL/6NCrl mice, a widely used mouse strain. Our data demonstrates a unique craniofacial skeletal development pattern in female C57BL/6NCrl mice, and differentiates the early vs. late craniofacial growth patterns. Additionally, our data documents the complex and differential changes in bone parameters (thickness, bone volume, bone volume/tissue volume, bone mineral density, and tissue mineral density) of various craniofacial bones with different embryonic origins and ossification mechanisms during postnatal growth, which underscores the complexity of craniofacial bone development and provides a reference standard for future quantitative analysis of craniofacial bones. |
| first_indexed | 2024-12-11T21:10:02Z |
| format | Article |
| id | doaj.art-83b8ff87aa32424cb8dbea3670fa25ee |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T21:10:02Z |
| publishDate | 2017-09-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj.art-83b8ff87aa32424cb8dbea3670fa25ee2022-12-22T00:50:44ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-09-01810.3389/fphys.2017.00697283217Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl MiceXiaoxi Wei0Xiaoxi Wei1Neil Thomas2Nan E. Hatch3Min Hu4Fei Liu5Department of Orthodontics, Jilin University School and Hospital of StomatologyChangchun, ChinaDepartment of Biologic and Materials Sciences and Division of Prosthodontics, University of Michigan School of DentistryAnn Arbor, MI, United StatesDepartment of Biologic and Materials Sciences and Division of Prosthodontics, University of Michigan School of DentistryAnn Arbor, MI, United StatesDepartment of Orthodontics and Pediatric Dentistry, University of Michigan School of DentistryAnn Arbor, MI, United StatesDepartment of Orthodontics, Jilin University School and Hospital of StomatologyChangchun, ChinaDepartment of Biologic and Materials Sciences and Division of Prosthodontics, University of Michigan School of DentistryAnn Arbor, MI, United StatesThe craniofacial skeleton is a complex and unique structure. The perturbation of its development can lead to craniofacial dysmorphology and associated morbidities. Our ability to prevent or mitigate craniofacial skeletal anomalies is at least partly dependent on our understanding of the unique physiological development of the craniofacial skeleton. Mouse models are critical tools for the study of craniofacial developmental abnormalities. However, there is a lack of detailed normative data of mouse craniofacial skeletal development in the literature. In this report, we employed high-resolution micro-computed tomography (μCT) in combination with morphometric measurements to analyze the postnatal craniofacial skeletal development from day 7 (P7) through day 390 (P390) of female C57BL/6NCrl mice, a widely used mouse strain. Our data demonstrates a unique craniofacial skeletal development pattern in female C57BL/6NCrl mice, and differentiates the early vs. late craniofacial growth patterns. Additionally, our data documents the complex and differential changes in bone parameters (thickness, bone volume, bone volume/tissue volume, bone mineral density, and tissue mineral density) of various craniofacial bones with different embryonic origins and ossification mechanisms during postnatal growth, which underscores the complexity of craniofacial bone development and provides a reference standard for future quantitative analysis of craniofacial bones.http://journal.frontiersin.org/article/10.3389/fphys.2017.00697/fullcranial basesynchondrosespostnatalcraniofacialmousebone |
| spellingShingle | Xiaoxi Wei Xiaoxi Wei Neil Thomas Nan E. Hatch Min Hu Fei Liu Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice Frontiers in Physiology cranial base synchondroses postnatal craniofacial mouse bone |
| title | Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice |
| title_full | Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice |
| title_fullStr | Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice |
| title_full_unstemmed | Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice |
| title_short | Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice |
| title_sort | postnatal craniofacial skeletal development of female c57bl 6ncrl mice |
| topic | cranial base synchondroses postnatal craniofacial mouse bone |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00697/full |
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