Neuroimmune interactions and their roles in neurodegenerative diseases
The nervous system possesses bidirectional, sophisticated and delicate communications with the immune system. These neuroimmune interactions play a vitally important role in the initiation and development of many disorders, especially neurodegenerative diseases. Although scientific advancements have...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2024-03-01
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| Series: | Fundamental Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325823001152 |
| _version_ | 1797248218174586880 |
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| author | Bai-Rong Chen Ting Wu Ting-Hui Chen Yun Wang |
| author_facet | Bai-Rong Chen Ting Wu Ting-Hui Chen Yun Wang |
| author_sort | Bai-Rong Chen |
| collection | DOAJ |
| description | The nervous system possesses bidirectional, sophisticated and delicate communications with the immune system. These neuroimmune interactions play a vitally important role in the initiation and development of many disorders, especially neurodegenerative diseases. Although scientific advancements have made tremendous progress in this field during the last few years, neuroimmune communications are still far from being elucidated. By organizing recent research, in this review, we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Unveiling these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains homeostasis. It will also facilitate a view of the diseases from a holistic, pluralistic and interconnected perspective, thus providing a basis of developing novel and effective methods to diagnose, intervene and treat diseases. |
| first_indexed | 2024-04-24T20:11:05Z |
| format | Article |
| id | doaj.art-83b97d77e8d4470bb0baa73f2a22de7b |
| institution | Directory Open Access Journal |
| issn | 2667-3258 |
| language | English |
| last_indexed | 2024-04-24T20:11:05Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj.art-83b97d77e8d4470bb0baa73f2a22de7b2024-03-23T06:26:38ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582024-03-0142251261Neuroimmune interactions and their roles in neurodegenerative diseasesBai-Rong Chen0Ting Wu1Ting-Hui Chen2Yun Wang3Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, ChinaNeuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, ChinaNeuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, ChinaNeuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China; Corresponding author.The nervous system possesses bidirectional, sophisticated and delicate communications with the immune system. These neuroimmune interactions play a vitally important role in the initiation and development of many disorders, especially neurodegenerative diseases. Although scientific advancements have made tremendous progress in this field during the last few years, neuroimmune communications are still far from being elucidated. By organizing recent research, in this review, we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Unveiling these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains homeostasis. It will also facilitate a view of the diseases from a holistic, pluralistic and interconnected perspective, thus providing a basis of developing novel and effective methods to diagnose, intervene and treat diseases.http://www.sciencedirect.com/science/article/pii/S2667325823001152Nervous systemImmune systemNeuroimmune interactionsAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis |
| spellingShingle | Bai-Rong Chen Ting Wu Ting-Hui Chen Yun Wang Neuroimmune interactions and their roles in neurodegenerative diseases Fundamental Research Nervous system Immune system Neuroimmune interactions Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis |
| title | Neuroimmune interactions and their roles in neurodegenerative diseases |
| title_full | Neuroimmune interactions and their roles in neurodegenerative diseases |
| title_fullStr | Neuroimmune interactions and their roles in neurodegenerative diseases |
| title_full_unstemmed | Neuroimmune interactions and their roles in neurodegenerative diseases |
| title_short | Neuroimmune interactions and their roles in neurodegenerative diseases |
| title_sort | neuroimmune interactions and their roles in neurodegenerative diseases |
| topic | Nervous system Immune system Neuroimmune interactions Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S2667325823001152 |
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