Knock Out of CGN and CGNL1 in MDCK Cells Affects Claudin-2 but Has a Minor Impact on Tight Junction Barrier Function

Knock Out of CGN and CGNL1 in MDCK Cells Affects Claudin-2 but Has a Minor Impact on Tight Junction Barrier Function

Cingulin (CGN) and paracingulin (CGNL1) are cytoplasmic proteins of tight junctions (TJs), where they play a role in tethering ZO-1 to the actomyosin and microtubule cytoskeletons. The role of CGN and CGNL1 in the barrier function of epithelia is not completely understood. Here, we analyzed the effe...

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Bibliographic Details
Main Authors: Marine Maupérin, Ali Sassi, Isabelle Méan, Eric Feraille, Sandra Citi
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
cingulin
paracingulin
permeability
sodium
claudin-2
Online Access:https://www.mdpi.com/2073-4409/12/15/2004

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