Diels–Alder Cycloaddition Reactions in Sustainable Media
Diels–Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. In this review, an insight into the most relevant advances on sustainable Diels–Alder reactions s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/4/1304 |
| _version_ | 1827653514873012224 |
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| author | Maria I. L. Soares Ana L. Cardoso Teresa M. V. D. Pinho e Melo |
| author_facet | Maria I. L. Soares Ana L. Cardoso Teresa M. V. D. Pinho e Melo |
| author_sort | Maria I. L. Soares |
| collection | DOAJ |
| description | Diels–Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. In this review, an insight into the most relevant advances on sustainable Diels–Alder reactions since 2010 is provided. Various environmentally benign solvent systems are discussed, namely bio-based derived solvents (such as glycerol and gluconic acid), polyethylene glycol, deep eutectic solvents, supercritical carbon dioxide, water and water-based aqueous systems. Issues such as method’s scope, efficiency, selectivity and reaction mechanism, as well as sustainability, advantages and limitations of these reaction media, are addressed. |
| first_indexed | 2024-03-09T21:20:55Z |
| format | Article |
| id | doaj.art-83bbbd3b2eca48b3b3e1b011944da7a0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:20:55Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-83bbbd3b2eca48b3b3e1b011944da7a02023-11-23T21:21:56ZengMDPI AGMolecules1420-30492022-02-01274130410.3390/molecules27041304Diels–Alder Cycloaddition Reactions in Sustainable MediaMaria I. L. Soares0Ana L. Cardoso1Teresa M. V. D. Pinho e Melo2University of Coimbra, Coimbra Chemistry Centre–Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, PortugalUniversity of Coimbra, Coimbra Chemistry Centre–Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, PortugalUniversity of Coimbra, Coimbra Chemistry Centre–Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, PortugalDiels–Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. In this review, an insight into the most relevant advances on sustainable Diels–Alder reactions since 2010 is provided. Various environmentally benign solvent systems are discussed, namely bio-based derived solvents (such as glycerol and gluconic acid), polyethylene glycol, deep eutectic solvents, supercritical carbon dioxide, water and water-based aqueous systems. Issues such as method’s scope, efficiency, selectivity and reaction mechanism, as well as sustainability, advantages and limitations of these reaction media, are addressed.https://www.mdpi.com/1420-3049/27/4/1304Diels–Alder reactiongreen solventbio-based solventdeep eutectic solventswater |
| spellingShingle | Maria I. L. Soares Ana L. Cardoso Teresa M. V. D. Pinho e Melo Diels–Alder Cycloaddition Reactions in Sustainable Media Molecules Diels–Alder reaction green solvent bio-based solvent deep eutectic solvents water |
| title | Diels–Alder Cycloaddition Reactions in Sustainable Media |
| title_full | Diels–Alder Cycloaddition Reactions in Sustainable Media |
| title_fullStr | Diels–Alder Cycloaddition Reactions in Sustainable Media |
| title_full_unstemmed | Diels–Alder Cycloaddition Reactions in Sustainable Media |
| title_short | Diels–Alder Cycloaddition Reactions in Sustainable Media |
| title_sort | diels alder cycloaddition reactions in sustainable media |
| topic | Diels–Alder reaction green solvent bio-based solvent deep eutectic solvents water |
| url | https://www.mdpi.com/1420-3049/27/4/1304 |
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