Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma
ObjectiveTo analyze the clinical features, ultrasonographic manifestations, pathological features, treatment and prognosis of primary thyroid squamous cell carcinoma (PSCTC) and summarize the experience in diagnosis and treatment of this condition.MethodsA retrospective analysis was conducted on pat...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.956289/full |
| _version_ | 1811215301149196288 |
|---|---|
| author | Di Ou Di Ou Chen Ni Jincao Yao Min Lai Chen Chen Yajiao Zhang Tian Jiang Tingting Qian Liping Wang Dong Xu Dong Xu |
| author_facet | Di Ou Di Ou Chen Ni Jincao Yao Min Lai Chen Chen Yajiao Zhang Tian Jiang Tingting Qian Liping Wang Dong Xu Dong Xu |
| author_sort | Di Ou |
| collection | DOAJ |
| description | ObjectiveTo analyze the clinical features, ultrasonographic manifestations, pathological features, treatment and prognosis of primary thyroid squamous cell carcinoma (PSCTC) and summarize the experience in diagnosis and treatment of this condition.MethodsA retrospective analysis was conducted on patients who were admitted to Zhejiang Cancer Hospital from 2007 to 2021 due to thyroid nodules or thyroid malignant tumors that were ultimately confirmed by postoperative pathology as primary thyroid squamous cell carcinoma. We summarize the general situation, clinical information, laboratory examination, ultrasonic image characteristics, pathological examination, clinical treatment and prognosis of the patients.ResultsPSCTC is most often seen in older men and progresses rapidly. In laboratory tests, some patients had elevated levels of tumor markers (CA199, squamous cell carcinoma antigen level), thyroglobulin levels and tumor-related substances, but all these indicators lacked specificity. The ultrasound features of PSCTC are mainly hypoechoic, hard, substantial nodules with gross borders and a grade 1-2 blood flow signal, sometimes with signs of necrosis and calcification. In terms of treatment, PSCTC is mainly surgically resected, though some patients in this study underwent iodine-131 radiation therapy, local radiotherapy, and chemotherapy with unclear results. None of the patients survived for very long after treatment, but the prognosis of patients with highly differentiated squamous carcinoma was significantly better than that of patients with poorly differentiated squamous carcinoma. Papillary thyroid carcinoma may be one of the causes of PSCTC.ConclusionPSCTC is a malignant tumor with high malignancy and rapid clinical progression. Treatment options are mainly based on surgical resection and can be supplemented with radiotherapy and chemotherapy, but there is still a lack of a standardized treatment management system, and more cases and reports are needed to accumulate data. |
| first_indexed | 2024-04-12T06:20:34Z |
| format | Article |
| id | doaj.art-83bc571467d0414c81517b7e05839997 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T06:20:34Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-83bc571467d0414c81517b7e058399972022-12-22T03:44:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.956289956289Clinical analysis of 13 cases of primary squamous-cell thyroid carcinomaDi Ou0Di Ou1Chen Ni2Jincao Yao3Min Lai4Chen Chen5Yajiao Zhang6Tian Jiang7Tingting Qian8Liping Wang9Dong Xu10Dong Xu11Department of Ultrasonography, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, ChinaKey Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Ultrasonography, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaGraduate School, Wannan Medical College, Hangzhou, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Postgraduate Training Base, Wen Zhou Medical University, Hangzhou, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Ultrasonography, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, ChinaKey Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, ChinaInstitute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, ChinaObjectiveTo analyze the clinical features, ultrasonographic manifestations, pathological features, treatment and prognosis of primary thyroid squamous cell carcinoma (PSCTC) and summarize the experience in diagnosis and treatment of this condition.MethodsA retrospective analysis was conducted on patients who were admitted to Zhejiang Cancer Hospital from 2007 to 2021 due to thyroid nodules or thyroid malignant tumors that were ultimately confirmed by postoperative pathology as primary thyroid squamous cell carcinoma. We summarize the general situation, clinical information, laboratory examination, ultrasonic image characteristics, pathological examination, clinical treatment and prognosis of the patients.ResultsPSCTC is most often seen in older men and progresses rapidly. In laboratory tests, some patients had elevated levels of tumor markers (CA199, squamous cell carcinoma antigen level), thyroglobulin levels and tumor-related substances, but all these indicators lacked specificity. The ultrasound features of PSCTC are mainly hypoechoic, hard, substantial nodules with gross borders and a grade 1-2 blood flow signal, sometimes with signs of necrosis and calcification. In terms of treatment, PSCTC is mainly surgically resected, though some patients in this study underwent iodine-131 radiation therapy, local radiotherapy, and chemotherapy with unclear results. None of the patients survived for very long after treatment, but the prognosis of patients with highly differentiated squamous carcinoma was significantly better than that of patients with poorly differentiated squamous carcinoma. Papillary thyroid carcinoma may be one of the causes of PSCTC.ConclusionPSCTC is a malignant tumor with high malignancy and rapid clinical progression. Treatment options are mainly based on surgical resection and can be supplemented with radiotherapy and chemotherapy, but there is still a lack of a standardized treatment management system, and more cases and reports are needed to accumulate data.https://www.frontiersin.org/articles/10.3389/fonc.2022.956289/fullthyroidprimary squamous-cell thyroid carcinomathyroid carcinomaultrasoundpathological features |
| spellingShingle | Di Ou Di Ou Chen Ni Jincao Yao Min Lai Chen Chen Yajiao Zhang Tian Jiang Tingting Qian Liping Wang Dong Xu Dong Xu Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma Frontiers in Oncology thyroid primary squamous-cell thyroid carcinoma thyroid carcinoma ultrasound pathological features |
| title | Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma |
| title_full | Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma |
| title_fullStr | Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma |
| title_full_unstemmed | Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma |
| title_short | Clinical analysis of 13 cases of primary squamous-cell thyroid carcinoma |
| title_sort | clinical analysis of 13 cases of primary squamous cell thyroid carcinoma |
| topic | thyroid primary squamous-cell thyroid carcinoma thyroid carcinoma ultrasound pathological features |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.956289/full |
| work_keys_str_mv | AT diou clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT diou clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT chenni clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT jincaoyao clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT minlai clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT chenchen clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT yajiaozhang clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT tianjiang clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT tingtingqian clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT lipingwang clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT dongxu clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma AT dongxu clinicalanalysisof13casesofprimarysquamouscellthyroidcarcinoma |