Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

As an adipokine in circulation, adiponectin has been extensively studied for its beneficial metabolic effects. While many important functions have been attributed to adiponectin under high-fat diet conditions, little is known about its essential role under regular chow. Employing a mouse model with...

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Bibliographic Details
Main Authors: Risheng Ye, William L Holland, Ruth Gordillo, Miao Wang, Qiong A Wang, Mengle Shao, Thomas S Morley, Rana K Gupta, Andreas Stahl, Philipp E Scherer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
adiponectin
insulin deficiency
lipid metabolism
islet lipotoxicity
β-cell regeneration
Online Access:https://elifesciences.org/articles/03851

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