Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes
The different types of diabetes differ in disease pathogenesis but share the impairment or loss of β-cell function leading to chronic hyperglycaemia. While immune cells are present throughout the whole pancreas in normality, their number and activation is increased in diabetes. Different patterns an...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-07-01
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| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/20420188231185958 |
| _version_ | 1797771639002234880 |
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| author | Nicole Kattner |
| author_facet | Nicole Kattner |
| author_sort | Nicole Kattner |
| collection | DOAJ |
| description | The different types of diabetes differ in disease pathogenesis but share the impairment or loss of β-cell function leading to chronic hyperglycaemia. While immune cells are present throughout the whole pancreas in normality, their number and activation is increased in diabetes. Different patterns and composition of inflammation could be observed in type 1, type 2 and type 3c diabetes. Immune cells, pancreatic stellate cells and fibrosis were present in the islet microenvironment and could add to β-cell dysfunction and therefore development and progression of diabetes. First studies investigating the use of anti-inflammatory drugs demonstrate their ability to rescue remaining β-cell function and their potential benefit in diabetes treatment. This article provides an overview of immune cell infiltrates in different types of diabetes, highlights the knowledge of their impact on β-cell function and introduces the potential of immunomodulatory strategies. |
| first_indexed | 2024-03-12T21:40:29Z |
| format | Article |
| id | doaj.art-83bff69a767744819324a57851700ae3 |
| institution | Directory Open Access Journal |
| issn | 2042-0196 |
| language | English |
| last_indexed | 2024-03-12T21:40:29Z |
| publishDate | 2023-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj.art-83bff69a767744819324a57851700ae32023-07-27T01:06:39ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01962023-07-011410.1177/20420188231185958Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetesNicole KattnerThe different types of diabetes differ in disease pathogenesis but share the impairment or loss of β-cell function leading to chronic hyperglycaemia. While immune cells are present throughout the whole pancreas in normality, their number and activation is increased in diabetes. Different patterns and composition of inflammation could be observed in type 1, type 2 and type 3c diabetes. Immune cells, pancreatic stellate cells and fibrosis were present in the islet microenvironment and could add to β-cell dysfunction and therefore development and progression of diabetes. First studies investigating the use of anti-inflammatory drugs demonstrate their ability to rescue remaining β-cell function and their potential benefit in diabetes treatment. This article provides an overview of immune cell infiltrates in different types of diabetes, highlights the knowledge of their impact on β-cell function and introduces the potential of immunomodulatory strategies.https://doi.org/10.1177/20420188231185958 |
| spellingShingle | Nicole Kattner Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes Therapeutic Advances in Endocrinology and Metabolism |
| title | Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes |
| title_full | Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes |
| title_fullStr | Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes |
| title_full_unstemmed | Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes |
| title_short | Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes |
| title_sort | immune cell infiltration in the pancreas of type 1 type 2 and type 3c diabetes |
| url | https://doi.org/10.1177/20420188231185958 |
| work_keys_str_mv | AT nicolekattner immunecellinfiltrationinthepancreasoftype1type2andtype3cdiabetes |