Sodium metabisulfite hypersensitivity in urticaria
Background: Sodium metabisulfite is a recognized, but rare, trigger of urticaria, wherein the IgE mechanism has been sporadically proven. The aim of this study was to identify the potential reaction to sodium metabisulfite (MBS) based on a placebo-controlled oral challenge in patients with...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Our Dermatology Online
2021-04-01
|
| Series: | Nasza Dermatologia Online |
| Online Access: | http://www.odermatol.com/issue-in-html/2021-2-2-urticaria/ |
| _version_ | 1797977136449978368 |
|---|---|
| author | Beata Sadowska Marlena Sztormowska Marika Gawinowska Marta Chelminska |
| author_facet | Beata Sadowska Marlena Sztormowska Marika Gawinowska Marta Chelminska |
| author_sort | Beata Sadowska |
| collection | DOAJ |
| description | Background: Sodium metabisulfite is a recognized, but rare, trigger of urticaria, wherein the IgE mechanism has been sporadically proven. The aim of this study was to identify the potential reaction to sodium metabisulfite (MBS) based on a placebo-controlled oral challenge in patients with urticaria and suspected hypersensitivity to food additives. Materials and Methods: A total of 110 adult patients (76 females and 34 males with a mean age of 46 years) were included in the study between 2017 and 2019. All subjects underwent MBS skin prick tests (SPT) and patch tests (PT). Patients with a positive skin test or suspected MBS hypersensitivity were qualified for a placebo-controlled oral challenge (OC). Results: Skin testing was positive in 24 patients: SPT in 20% (n = 22), PT in 5% (n = 6). Out of 64 oral challenges, 13 positive results were obtained. Patients with a positive challenge typed sulfite foods twice as often as a culprit compared to those with a negative OC. Conclusions: In patients with urticaria, both the IgE and non-IgE mechanism of MBS hypersensitivity has been demonstrated. Skin tests with a detailed medical history of potentially guilty foods may be helpful in determining sulfite hypersensitivity. |
| first_indexed | 2024-04-11T05:02:08Z |
| format | Article |
| id | doaj.art-83c004c7980648e2b0fe4539ac7fd101 |
| institution | Directory Open Access Journal |
| issn | 2081-9390 |
| language | English |
| last_indexed | 2024-04-11T05:02:08Z |
| publishDate | 2021-04-01 |
| publisher | Our Dermatology Online |
| record_format | Article |
| series | Nasza Dermatologia Online |
| spelling | doaj.art-83c004c7980648e2b0fe4539ac7fd1012022-12-25T16:06:49ZengOur Dermatology OnlineNasza Dermatologia Online2081-93902021-04-0112210611210.7241/ourd.20212.2Sodium metabisulfite hypersensitivity in urticariaBeata SadowskaMarlena SztormowskaMarika GawinowskaMarta Chelminska Background: Sodium metabisulfite is a recognized, but rare, trigger of urticaria, wherein the IgE mechanism has been sporadically proven. The aim of this study was to identify the potential reaction to sodium metabisulfite (MBS) based on a placebo-controlled oral challenge in patients with urticaria and suspected hypersensitivity to food additives. Materials and Methods: A total of 110 adult patients (76 females and 34 males with a mean age of 46 years) were included in the study between 2017 and 2019. All subjects underwent MBS skin prick tests (SPT) and patch tests (PT). Patients with a positive skin test or suspected MBS hypersensitivity were qualified for a placebo-controlled oral challenge (OC). Results: Skin testing was positive in 24 patients: SPT in 20% (n = 22), PT in 5% (n = 6). Out of 64 oral challenges, 13 positive results were obtained. Patients with a positive challenge typed sulfite foods twice as often as a culprit compared to those with a negative OC. Conclusions: In patients with urticaria, both the IgE and non-IgE mechanism of MBS hypersensitivity has been demonstrated. Skin tests with a detailed medical history of potentially guilty foods may be helpful in determining sulfite hypersensitivity.http://www.odermatol.com/issue-in-html/2021-2-2-urticaria/ |
| spellingShingle | Beata Sadowska Marlena Sztormowska Marika Gawinowska Marta Chelminska Sodium metabisulfite hypersensitivity in urticaria Nasza Dermatologia Online |
| title | Sodium metabisulfite hypersensitivity in urticaria |
| title_full | Sodium metabisulfite hypersensitivity in urticaria |
| title_fullStr | Sodium metabisulfite hypersensitivity in urticaria |
| title_full_unstemmed | Sodium metabisulfite hypersensitivity in urticaria |
| title_short | Sodium metabisulfite hypersensitivity in urticaria |
| title_sort | sodium metabisulfite hypersensitivity in urticaria |
| url | http://www.odermatol.com/issue-in-html/2021-2-2-urticaria/ |
| work_keys_str_mv | AT beatasadowska sodiummetabisulfitehypersensitivityinurticaria AT marlenasztormowska sodiummetabisulfitehypersensitivityinurticaria AT marikagawinowska sodiummetabisulfitehypersensitivityinurticaria AT martachelminska sodiummetabisulfitehypersensitivityinurticaria |