The effect and mechanism of exercise for post-stroke pain
One of the common negative effects of a stroke that seriously lowers patients’ quality of life is post-stroke pain (PSP). Thus, exercise in PSP management has become a hot research topic. The main advantages of exercise therapy are affordability and ease of acceptance by patients compared to other t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1074205/full |
| _version_ | 1828289173309620224 |
|---|---|
| author | Yue Ma Jing Luo Xue-Qiang Wang Xue-Qiang Wang |
| author_facet | Yue Ma Jing Luo Xue-Qiang Wang Xue-Qiang Wang |
| author_sort | Yue Ma |
| collection | DOAJ |
| description | One of the common negative effects of a stroke that seriously lowers patients’ quality of life is post-stroke pain (PSP). Thus, exercise in PSP management has become a hot research topic. The main advantages of exercise therapy are affordability and ease of acceptance by patients compared to other treatment methods. Therefore, this article reviews the effectiveness and possible mechanisms of exercise interventions for PSP. Exercise training for patients with PSP not only improves physical function but also effectively reduces pain intensity and attenuates the behavioral response to pain. In addition, exercise therapy can improve brain function and modulate levels of pro-inflammatory and neurotrophic factors to exert specific analgesic effects. Potential mechanisms for exercise intervention include modulation of synaptic plasticity in the anterior cingulate gyrus, modulation of endogenous opioids in vivo, reversal of brain-derived neurotrophic factor overexpression, inhibition of purinergic receptor (P2X4R, P2X7R) expression, and inhibition of microglia activation. However, current research on exercise for PSP remains limited, and the sustainable benefits of exercise interventions for PSP need to be further investigated. |
| first_indexed | 2024-04-13T10:17:32Z |
| format | Article |
| id | doaj.art-83c0115b094a4d8a820b49bba20ad947 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T10:17:32Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-83c0115b094a4d8a820b49bba20ad9472022-12-22T02:50:40ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-12-011510.3389/fnmol.2022.10742051074205The effect and mechanism of exercise for post-stroke painYue Ma0Jing Luo1Xue-Qiang Wang2Xue-Qiang Wang3Department of Sport Rehabilitation, Xi’an Physical Education University, Xi’an, ChinaDepartment of Sport Rehabilitation, Xi’an Physical Education University, Xi’an, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, Shanghai, ChinaOne of the common negative effects of a stroke that seriously lowers patients’ quality of life is post-stroke pain (PSP). Thus, exercise in PSP management has become a hot research topic. The main advantages of exercise therapy are affordability and ease of acceptance by patients compared to other treatment methods. Therefore, this article reviews the effectiveness and possible mechanisms of exercise interventions for PSP. Exercise training for patients with PSP not only improves physical function but also effectively reduces pain intensity and attenuates the behavioral response to pain. In addition, exercise therapy can improve brain function and modulate levels of pro-inflammatory and neurotrophic factors to exert specific analgesic effects. Potential mechanisms for exercise intervention include modulation of synaptic plasticity in the anterior cingulate gyrus, modulation of endogenous opioids in vivo, reversal of brain-derived neurotrophic factor overexpression, inhibition of purinergic receptor (P2X4R, P2X7R) expression, and inhibition of microglia activation. However, current research on exercise for PSP remains limited, and the sustainable benefits of exercise interventions for PSP need to be further investigated.https://www.frontiersin.org/articles/10.3389/fnmol.2022.1074205/fullstrokepost-stroke painexerciseanalgesic effectanalgesic mechanism |
| spellingShingle | Yue Ma Jing Luo Xue-Qiang Wang Xue-Qiang Wang The effect and mechanism of exercise for post-stroke pain Frontiers in Molecular Neuroscience stroke post-stroke pain exercise analgesic effect analgesic mechanism |
| title | The effect and mechanism of exercise for post-stroke pain |
| title_full | The effect and mechanism of exercise for post-stroke pain |
| title_fullStr | The effect and mechanism of exercise for post-stroke pain |
| title_full_unstemmed | The effect and mechanism of exercise for post-stroke pain |
| title_short | The effect and mechanism of exercise for post-stroke pain |
| title_sort | effect and mechanism of exercise for post stroke pain |
| topic | stroke post-stroke pain exercise analgesic effect analgesic mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1074205/full |
| work_keys_str_mv | AT yuema theeffectandmechanismofexerciseforpoststrokepain AT jingluo theeffectandmechanismofexerciseforpoststrokepain AT xueqiangwang theeffectandmechanismofexerciseforpoststrokepain AT xueqiangwang theeffectandmechanismofexerciseforpoststrokepain AT yuema effectandmechanismofexerciseforpoststrokepain AT jingluo effectandmechanismofexerciseforpoststrokepain AT xueqiangwang effectandmechanismofexerciseforpoststrokepain AT xueqiangwang effectandmechanismofexerciseforpoststrokepain |