Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer death. In recent years, studies have suggested that intestinal microbiota dysregulation is closely related to HCC and can affect the therapeutic efficacy of immune checkpoint inhibitors. However, there are few data on the relat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/2/141 |
| _version_ | 1827757904752541696 |
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| author | Ran Huo Yanlin Chen Jie Li Quanguo Xu Junying Guo Haiyan Xu Yiqing You Chaoqiang Zheng Yan Chen |
| author_facet | Ran Huo Yanlin Chen Jie Li Quanguo Xu Junying Guo Haiyan Xu Yiqing You Chaoqiang Zheng Yan Chen |
| author_sort | Ran Huo |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer death. In recent years, studies have suggested that intestinal microbiota dysregulation is closely related to HCC and can affect the therapeutic efficacy of immune checkpoint inhibitors. However, there are few data on the relationship between altered gut microbiota composition and its potential association in patients with advanced hepatocellular carcinoma. Hence, in this study, we aimed to investigate the gut microbiota profile associated with advanced hepatocarcinoma. In total, 20 patients with advanced hepatocarcinoma and 20 matched healthy participants were recruited. Stool samples were collected for 16S rRNA sequencing to confirm intestinal microbiota dysbiosis. The results showed that the Nseqs index in advanced hepatocarcinoma patients was significantly different compared with that in healthy individuals, while the butyrate-producing bacteria decreased and LPS-producing bacteria increased. Meanwhile, <i>Lactobacillus</i>, <i>Anaerostipes</i>, <i>Fusicatenibacter</i>, <i>Bifidobacterium</i>, and <i>Faecalibacterium</i> were significantly correlated with AFP, ALT, AST, and PIVKA. Our findings characterized the gut microbiota composition of advanced hepatocarcinoma, providing an experimental basis and theoretical support for using microbiota to regulate immunotherapy, achieve potential biomarkers for diagnosis, and improve the effect of clinical treatment for patients with advanced hepatocarcinoma. |
| first_indexed | 2024-03-11T08:58:01Z |
| format | Article |
| id | doaj.art-83c0195e851745f6b2a78ec78c93d04b |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T08:58:01Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-83c0195e851745f6b2a78ec78c93d04b2023-11-16T19:57:53ZengMDPI AGCurrent Oncology1198-00521718-77292023-02-013021818183010.3390/curroncol30020141Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular CarcinomaRan Huo0Yanlin Chen1Jie Li2Quanguo Xu3Junying Guo4Haiyan Xu5Yiqing You6Chaoqiang Zheng7Yan Chen8Department of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou 635000, ChinaSchool of Pharmacy and Medical Technology, Putian University, Putian 351100, ChinaDepartment of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaDepartment of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, ChinaHepatocellular carcinoma (HCC) is the second-most-common cause of cancer death. In recent years, studies have suggested that intestinal microbiota dysregulation is closely related to HCC and can affect the therapeutic efficacy of immune checkpoint inhibitors. However, there are few data on the relationship between altered gut microbiota composition and its potential association in patients with advanced hepatocellular carcinoma. Hence, in this study, we aimed to investigate the gut microbiota profile associated with advanced hepatocarcinoma. In total, 20 patients with advanced hepatocarcinoma and 20 matched healthy participants were recruited. Stool samples were collected for 16S rRNA sequencing to confirm intestinal microbiota dysbiosis. The results showed that the Nseqs index in advanced hepatocarcinoma patients was significantly different compared with that in healthy individuals, while the butyrate-producing bacteria decreased and LPS-producing bacteria increased. Meanwhile, <i>Lactobacillus</i>, <i>Anaerostipes</i>, <i>Fusicatenibacter</i>, <i>Bifidobacterium</i>, and <i>Faecalibacterium</i> were significantly correlated with AFP, ALT, AST, and PIVKA. Our findings characterized the gut microbiota composition of advanced hepatocarcinoma, providing an experimental basis and theoretical support for using microbiota to regulate immunotherapy, achieve potential biomarkers for diagnosis, and improve the effect of clinical treatment for patients with advanced hepatocarcinoma.https://www.mdpi.com/1718-7729/30/2/141advanced hepatocellular carcinomagut microbiota dysbiosis16S rRNAgut microbiota biomarkersimmunotherapy |
| spellingShingle | Ran Huo Yanlin Chen Jie Li Quanguo Xu Junying Guo Haiyan Xu Yiqing You Chaoqiang Zheng Yan Chen Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma Current Oncology advanced hepatocellular carcinoma gut microbiota dysbiosis 16S rRNA gut microbiota biomarkers immunotherapy |
| title | Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma |
| title_full | Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma |
| title_fullStr | Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma |
| title_full_unstemmed | Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma |
| title_short | Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma |
| title_sort | altered gut microbiota composition and its potential association in patients with advanced hepatocellular carcinoma |
| topic | advanced hepatocellular carcinoma gut microbiota dysbiosis 16S rRNA gut microbiota biomarkers immunotherapy |
| url | https://www.mdpi.com/1718-7729/30/2/141 |
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