The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review
Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/11/3/297 |
| _version_ | 1818527089019584512 |
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| author | Kena Song Guoqiang Li Xiangyang Zu Zhe Du Liyu Liu Zhigang Hu |
| author_facet | Kena Song Guoqiang Li Xiangyang Zu Zhe Du Liyu Liu Zhigang Hu |
| author_sort | Kena Song |
| collection | DOAJ |
| description | Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future. |
| first_indexed | 2024-12-11T06:31:35Z |
| format | Article |
| id | doaj.art-83c07db6bb544192becbe283899e5214 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-11T06:31:35Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-83c07db6bb544192becbe283899e52142022-12-22T01:17:30ZengMDPI AGMicromachines2072-666X2020-03-0111329710.3390/mi11030297mi11030297The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A ReviewKena Song0Guoqiang Li1Xiangyang Zu2Zhe Du3Liyu Liu4Zhigang Hu5College of Medical Technology and Engineering, Henan University of Science and Technology, He’nan 471023, ChinaCollege of Physics, Chongqing University, Chongqing 401331, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, He’nan 471023, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, He’nan 471023, ChinaCollege of Physics, Chongqing University, Chongqing 401331, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, He’nan 471023, ChinaMicrofluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future.https://www.mdpi.com/2072-666X/11/3/297microfluidicscaffoldstructurematerialmechanismextracellular matrix (ecm) |
| spellingShingle | Kena Song Guoqiang Li Xiangyang Zu Zhe Du Liyu Liu Zhigang Hu The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review Micromachines microfluidic scaffold structure material mechanism extracellular matrix (ecm) |
| title | The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review |
| title_full | The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review |
| title_fullStr | The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review |
| title_full_unstemmed | The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review |
| title_short | The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review |
| title_sort | fabrication and application mechanism of microfluidic systems for high throughput biomedical screening a review |
| topic | microfluidic scaffold structure material mechanism extracellular matrix (ecm) |
| url | https://www.mdpi.com/2072-666X/11/3/297 |
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