Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young
Purpose We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2020.1829458 |
| _version_ | 1797685086464770048 |
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| author | Wei Zhang Jian-Zhong Xu Xiao-Hong Lu Hua Li Dian Wang Ji-Guang Wang |
| author_facet | Wei Zhang Jian-Zhong Xu Xiao-Hong Lu Hua Li Dian Wang Ji-Guang Wang |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Purpose We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. Materials and methods A total of 616 study participants were 10–24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisation. 24-h urine was collected for measurements of electrolytes. Hyperuricaemia was defined as a serum uric acid of ≥327.25 μmol/L in patients <18 years old and of ≥420 and ≥360 μmol/L, respectively, in male and female patients ≥18 years old. Results In adjusted analyses, patients with hyperuricaemia (n = 283), compared with those with normal serum uric acid, had similar 24-h systolic BP (131.7 mmHg, p = 0.54) and a significantly (p ≤ 0.005) lower 24-h diastolic BP (77.5 vs. 80.9 mmHg) and higher 24-h pulse pressure (54.2 vs. 51.7 mmHg). In similar adjusted analyses, 24-h ambulatory pulse pressure, but not systolic/diastolic BP (p ≥ 0.12), significantly differed across the quartile distributions of urinary sodium excretion (p for trend ≤ 0.04). Further adjusted analyses showed significant (p ≤ 0.04) interaction between serum uric acid and urinary sodium excretion in relation to 24-h systolic BP. In patients with hyperuricaemia (p = 0.04), but not those with normal serum uric acid (p = 0.13), 24-h systolic BP was significantly associated with urinary sodium excretion, with a 6.5 ± 2.1 mmHg difference between quartiles 4 and 1. Similar results were observed for daytime and night-time BP and pulse pressure. Conclusions Both hyperuricaemia and higher dietary sodium intake were associated with higher pulse pressure, and their interaction further heightened systolic BP. |
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| id | doaj.art-83c17acb79d84f8f93aada6ad557873c |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:13Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-83c17acb79d84f8f93aada6ad557873c2023-09-15T08:45:23ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992021-01-01301606610.1080/08037051.2020.18294581829458Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the youngWei Zhang0Jian-Zhong Xu1Xiao-Hong Lu2Hua Li3Dian Wang4Ji-Guang Wang5Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of HypertensionDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of HypertensionDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of HypertensionDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of HypertensionDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of HypertensionDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of HypertensionPurpose We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. Materials and methods A total of 616 study participants were 10–24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisation. 24-h urine was collected for measurements of electrolytes. Hyperuricaemia was defined as a serum uric acid of ≥327.25 μmol/L in patients <18 years old and of ≥420 and ≥360 μmol/L, respectively, in male and female patients ≥18 years old. Results In adjusted analyses, patients with hyperuricaemia (n = 283), compared with those with normal serum uric acid, had similar 24-h systolic BP (131.7 mmHg, p = 0.54) and a significantly (p ≤ 0.005) lower 24-h diastolic BP (77.5 vs. 80.9 mmHg) and higher 24-h pulse pressure (54.2 vs. 51.7 mmHg). In similar adjusted analyses, 24-h ambulatory pulse pressure, but not systolic/diastolic BP (p ≥ 0.12), significantly differed across the quartile distributions of urinary sodium excretion (p for trend ≤ 0.04). Further adjusted analyses showed significant (p ≤ 0.04) interaction between serum uric acid and urinary sodium excretion in relation to 24-h systolic BP. In patients with hyperuricaemia (p = 0.04), but not those with normal serum uric acid (p = 0.13), 24-h systolic BP was significantly associated with urinary sodium excretion, with a 6.5 ± 2.1 mmHg difference between quartiles 4 and 1. Similar results were observed for daytime and night-time BP and pulse pressure. Conclusions Both hyperuricaemia and higher dietary sodium intake were associated with higher pulse pressure, and their interaction further heightened systolic BP.http://dx.doi.org/10.1080/08037051.2020.1829458primary hypertensionadolescentsambulatory blood pressureserum uric acidurinary sodium excretion |
| spellingShingle | Wei Zhang Jian-Zhong Xu Xiao-Hong Lu Hua Li Dian Wang Ji-Guang Wang Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young Blood Pressure primary hypertension adolescents ambulatory blood pressure serum uric acid urinary sodium excretion |
| title | Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young |
| title_full | Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young |
| title_fullStr | Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young |
| title_full_unstemmed | Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young |
| title_short | Ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young |
| title_sort | ambulatory blood pressure in relation to interaction between dietary sodium intake and serum uric acid in the young |
| topic | primary hypertension adolescents ambulatory blood pressure serum uric acid urinary sodium excretion |
| url | http://dx.doi.org/10.1080/08037051.2020.1829458 |
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