Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fncir.2017.00102/full |
| _version_ | 1818350427608973312 |
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| author | Holger Dannenberg Kimberly Young Michael Hasselmo |
| author_facet | Holger Dannenberg Kimberly Young Michael Hasselmo |
| author_sort | Holger Dannenberg |
| collection | DOAJ |
| description | This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons. |
| first_indexed | 2024-12-13T18:21:41Z |
| format | Article |
| id | doaj.art-83c2a942d0ff4bb3b1ad4875d83d005f |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-13T18:21:41Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-83c2a942d0ff4bb3b1ad4875d83d005f2022-12-21T23:35:41ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102017-12-011110.3389/fncir.2017.00102315341Modulation of Hippocampal Circuits by Muscarinic and Nicotinic ReceptorsHolger Dannenberg0Kimberly Young1Michael Hasselmo2enter for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, United Statesenter for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, United Statesenter for Systems Neuroscience, Department of Psychological and Brain Sciences, Boston University, Boston, MA, United StatesThis article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons.http://journal.frontiersin.org/article/10.3389/fncir.2017.00102/fullacetylcholinepresynaptic inhibitiontonic depolarizationcholinergic fibersvolume transmission |
| spellingShingle | Holger Dannenberg Kimberly Young Michael Hasselmo Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors Frontiers in Neural Circuits acetylcholine presynaptic inhibition tonic depolarization cholinergic fibers volume transmission |
| title | Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors |
| title_full | Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors |
| title_fullStr | Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors |
| title_full_unstemmed | Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors |
| title_short | Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors |
| title_sort | modulation of hippocampal circuits by muscarinic and nicotinic receptors |
| topic | acetylcholine presynaptic inhibition tonic depolarization cholinergic fibers volume transmission |
| url | http://journal.frontiersin.org/article/10.3389/fncir.2017.00102/full |
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