Neural stem cell-derived extracellular vesicles: The light of central nervous system diseases
Central nervous system (CNS) diseases are the leading cause of death worldwide. By performing compensatory functions and improving the inflammatory microenvironment, the transplantation of neural stem cells (NSCs) can promote functional recovery from brain injury, aging, brain tumours, and other dis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223008831 |
| _version_ | 1797744139318591488 |
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| author | Yuanyuan Li Bo Fang |
| author_facet | Yuanyuan Li Bo Fang |
| author_sort | Yuanyuan Li |
| collection | DOAJ |
| description | Central nervous system (CNS) diseases are the leading cause of death worldwide. By performing compensatory functions and improving the inflammatory microenvironment, the transplantation of neural stem cells (NSCs) can promote functional recovery from brain injury, aging, brain tumours, and other diseases. However, the ability of NSCs to differentiate into neurons is limited, and they are associated with a risk of tumourigenicity. NSC-derived extracellular vesicles (NSC-EVs) can modulate the local microenvironment of the nervous system as well as distant neuronal functions. Thus, cell-free therapy may be a novel remedy for CNS disorders. This article reviews the characteristics, contents, and mechanisms of action of NSC-EVs as well as their roles and application prospects in various CNS diseases. |
| first_indexed | 2024-03-12T15:05:26Z |
| format | Article |
| id | doaj.art-83c40f6a72774ffba8fef38cdd655317 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:05:26Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-83c40f6a72774ffba8fef38cdd6553172023-08-13T04:52:33ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115092Neural stem cell-derived extracellular vesicles: The light of central nervous system diseasesYuanyuan Li0Bo Fang1Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaCorrespondence to: Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.; Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaCentral nervous system (CNS) diseases are the leading cause of death worldwide. By performing compensatory functions and improving the inflammatory microenvironment, the transplantation of neural stem cells (NSCs) can promote functional recovery from brain injury, aging, brain tumours, and other diseases. However, the ability of NSCs to differentiate into neurons is limited, and they are associated with a risk of tumourigenicity. NSC-derived extracellular vesicles (NSC-EVs) can modulate the local microenvironment of the nervous system as well as distant neuronal functions. Thus, cell-free therapy may be a novel remedy for CNS disorders. This article reviews the characteristics, contents, and mechanisms of action of NSC-EVs as well as their roles and application prospects in various CNS diseases.http://www.sciencedirect.com/science/article/pii/S0753332223008831Cell communicationNon-coding RNAAlzheimer’s diseaseParkinson’s diseaseGliomaStroke |
| spellingShingle | Yuanyuan Li Bo Fang Neural stem cell-derived extracellular vesicles: The light of central nervous system diseases Biomedicine & Pharmacotherapy Cell communication Non-coding RNA Alzheimer’s disease Parkinson’s disease Glioma Stroke |
| title | Neural stem cell-derived extracellular vesicles: The light of central nervous system diseases |
| title_full | Neural stem cell-derived extracellular vesicles: The light of central nervous system diseases |
| title_fullStr | Neural stem cell-derived extracellular vesicles: The light of central nervous system diseases |
| title_full_unstemmed | Neural stem cell-derived extracellular vesicles: The light of central nervous system diseases |
| title_short | Neural stem cell-derived extracellular vesicles: The light of central nervous system diseases |
| title_sort | neural stem cell derived extracellular vesicles the light of central nervous system diseases |
| topic | Cell communication Non-coding RNA Alzheimer’s disease Parkinson’s disease Glioma Stroke |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223008831 |
| work_keys_str_mv | AT yuanyuanli neuralstemcellderivedextracellularvesiclesthelightofcentralnervoussystemdiseases AT bofang neuralstemcellderivedextracellularvesiclesthelightofcentralnervoussystemdiseases |