Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique...

Full description

Bibliographic Details
Main Authors:	Hyeongmin Kim, Chung-Lyol Lee, Seohyun Lee, Tae Jin Lee, Iqra Haleem, Younghong Lee, Na Jung Hwang, Kyusun Shim, Dohyun Kim, Jaehwi Lee
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Pharmaceutics
Subjects:	swelling gastroretentive system cogrinding technique freeze–thawing method β-lapachone dissolution behavior mechanical strength
Online Access:	https://www.mdpi.com/1999-4923/11/6/271

Similar Items

Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers
by: Mohammad Barzegar-jalali, et al.
Published: (2014-09-01)

Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
by: Danielly C. Ferraz da Costa, et al.
Published: (2020-02-01)

In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms
by: Felix Schneider, et al.
Published: (2019-08-01)

Cytotoxicity assessment of beta-lapachone in endothelial cells
by: Patrícia de Almeida Machado Gonçalves, et al.
Published: (2021-04-01)

Formulation and evaluation of gastroretentive-floating multiparticulate system of lisinopril
by: Manasa Moganti, et al.
Published: (2017-01-01)

In vitro synergic effect of ²-lapachone and isoniazid on the growth of Mycobacterium fortuitum and Mycobacterium smegmatis
by: Joas L da Silva, et al.
Published: (2009-07-01)

Evaluation of acute toxicity of β-lapachone associated with chitosan as a cytoprotective agent
by: Maria Eduarda F. A. G. Oliveira, et al.
Published: (2018-10-01)

Formulation and characterization of gastroretentive discs containing famotidine
by: Jignyasha Amitkumar Raval, et al.
Published: (2011-04-01)

Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities
by: Mariana F. do C. Cardoso, et al.
Published: (2017-02-01)

Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
by: Amit Porwal, et al.
Published: (2017-10-01)

Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (<i>sf</i>GRDDS) for Enhanced Oral Bioavailability of Nilotinib
by: Hong-Liang Lin, et al.
Published: (2020-02-01)

Antibacterial and Antibiofilm Activities of β-Lapachone by Modulating the Catalase Enzyme
by: Mushtaq Ahmad Mir, et al.
Published: (2023-03-01)

Formulation of metoclopramide HCl gastroretentive film and in vitro- in silico prediction using Gastroplus® PBPK software
by: Dalia Safaa Hamdi, et al.
Published: (2022-12-01)

Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells
by: Eun K. Choi, et al.
Published: (2007-08-01)

Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution
by: Sooho Yeo, et al.
Published: (2020-04-01)

Design, preparation, and in vitro evaluation of gastroretentive floating matrix tablet of mitiglinide
by: Meenakshi Patel, et al.
Published: (2023-03-01)

Glutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity
by: Walaa Ebrahim Abd El Hady, et al.
Published: (2021-01-01)

Development and evaluation of gastroretentive floating tablets of an antidepressant drug by thermoplastic granulation technique
by: Harshal Ashok Pawar, et al.
Published: (2014-06-01)

β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos
by: Huang Chang-Jen, et al.
Published: (2011-09-01)

Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix
by: Agata Kowalczyk, et al.
Published: (2020-08-01)

Beta-Lapachone Attenuates BMSC-Mediated Neuroblastoma Malignant Transformation by Inhibiting Gal-3/Gal-3BP/IL6 Axis
by: Yang Zhou, et al.
Published: (2021-11-01)

Enhancement of Aqueous Solubility and Dissolution of Celecoxib through Phosphatidylcholine-Based Dispersion Systems Solidified with Adsorbent Carriers
by: Kanghee Jo, et al.
Published: (2018-12-01)

Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells
by: Marcilia P. Costa, et al.
Published: (2016-07-01)

Effects of a novel β–lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis
by: Danielle Oliveira dos Anjos, et al.
Published: (2016-12-01)

β-LAPachone is renoprotective in streptozotocin-induced diabetic mice via regulating the PI3K/Akt/mTOR signaling pathway
by: Davoud Sanajou, et al.
Published: (2021-05-01)

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
by: Ajkia Zaman Juthi, et al.
Published: (2023-03-01)

Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design
by: Moganti Manasa, et al.
Published: (2021-01-01)

β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells
by: Eun Joo Jung, et al.
Published: (2023-06-01)

<i>Artemisia annua</i> L. Polyphenols Enhance the Anticancer Effect of β-Lapachone in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells
by: Eun Joo Jung, et al.
Published: (2023-12-01)

Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer cells
by: Jesús Calahorra, et al.
Published: (2024-05-01)

Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
by: Du F, et al.
Published: (2019-07-01)

Current State and Future Perspectives on Gastroretentive Drug Delivery Systems
by: Julu Tripathi, et al.
Published: (2019-04-01)

3D-Printed Gastroretentive Tablets Loaded with Niclosamide Nanocrystals by the Melting Solidification Printing Process (MESO-PP)
by: Juan Pablo Real, et al.
Published: (2023-04-01)

PREPARATION AND CHARACTERIZATION OF CO-PROCESSED EXCIPIENT-PREGELATINIZED CASSAVA STARCH PROPIONATE AS A MATRIX IN THE GASTRORETENTIVE DOSAGE FORM
by: Junaedi, et al.
Published: (2011-11-01)

Enhanced gastric therapeutic effects of Brucea javanica oil and its gastroretentive drug delivery system compared to commercial products in pharmacokinetics study
by: Zhang Y, et al.
Published: (2018-03-01)

MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer
by: Kirtikar Shukla, et al.
Published: (2020-11-01)

In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in <i>Leishmania</i> spp.
by: Juliana Figueiredo Peixoto, et al.
Published: (2021-06-01)

Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films
by: Worrawee Siripruekpong, et al.
Published: (2023-01-01)

Spray-Dried Silica Xerogel Nanoparticles as a Promising Gastroretentive Carrier System for the Management of Chemotherapy-Induced Nausea and Vomiting
by: Ghoneim AM, et al.
Published: (2019-12-01)

A Micro-In-Macro Gastroretentive System for the Delivery of Narrow-Absorption Window Drugs
by: Mershen Govender, et al.
Published: (2023-03-01)