Latent tuberculosis infection in children and adolescents in Russia
Background: After the breakup of the Soviet Union, the annual incidence of tuberculosis (TB) in children 15–17 years of age increased in the Russian Federation from 16 per 100 000 population in 1992 to 37 per 100 000 in 2009, and new control measures were implemented. Methods: Children were screened...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220300965 |
| _version_ | 1819276949686583296 |
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| author | Valentina Alexandrovna Aksenova Irina Anatolievna Vasilyeva Tereza Chermenovna Kasaeva Anastasia Gennadievna Samoilova Natalia Yurievna Pshenichnaya Tatyana Evgenievna Tyulkova |
| author_facet | Valentina Alexandrovna Aksenova Irina Anatolievna Vasilyeva Tereza Chermenovna Kasaeva Anastasia Gennadievna Samoilova Natalia Yurievna Pshenichnaya Tatyana Evgenievna Tyulkova |
| author_sort | Valentina Alexandrovna Aksenova |
| collection | DOAJ |
| description | Background: After the breakup of the Soviet Union, the annual incidence of tuberculosis (TB) in children 15–17 years of age increased in the Russian Federation from 16 per 100 000 population in 1992 to 37 per 100 000 in 2009, and new control measures were implemented. Methods: Children were screened annually for TB exposure with a tuberculin skin test (TST) at age 1–8 years. If positive, they were investigated for active TB. If no active TB was found, they were treated with isoniazid for 4–6 months; they then underwent 6-monthly skin tests (which included two recombinant proteins) until negative and annual skin tests thereafter. From the age of 8 years, the yearly follow-up was performed using the skin test that included two recombinant proteins, either until they became negative, developed active TB, or turned 18 years. Results: The annual incidence of TB in Russian children decreased from 19.1 per 100 000 population in 2001 to 8.3 per 100 000 population in 2018. Conclusions: Annual screening for TB exposure with treatment for latent or active TB has reduced the annual incidence of TB in Russian children aged 15–17 years to 1992 levels. Keywords: Latent tuberculosis, Screening of children and adolescents, Recombinant tuberculosis antigen |
| first_indexed | 2024-12-23T23:48:21Z |
| format | Article |
| id | doaj.art-83c65bf8a26544a383076d09b75259d6 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-23T23:48:21Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-83c65bf8a26544a383076d09b75259d62022-12-21T17:25:27ZengElsevierInternational Journal of Infectious Diseases1201-97122020-03-0192S26S30Latent tuberculosis infection in children and adolescents in RussiaValentina Alexandrovna Aksenova0Irina Anatolievna Vasilyeva1Tereza Chermenovna Kasaeva2Anastasia Gennadievna Samoilova3Natalia Yurievna Pshenichnaya4Tatyana Evgenievna Tyulkova5National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, RussiaNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, RussiaNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russia; Global TB Programme, World Health Organization, Geneva, SwitzerlandNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, RussiaNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russia; Corresponding author.National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, RussiaBackground: After the breakup of the Soviet Union, the annual incidence of tuberculosis (TB) in children 15–17 years of age increased in the Russian Federation from 16 per 100 000 population in 1992 to 37 per 100 000 in 2009, and new control measures were implemented. Methods: Children were screened annually for TB exposure with a tuberculin skin test (TST) at age 1–8 years. If positive, they were investigated for active TB. If no active TB was found, they were treated with isoniazid for 4–6 months; they then underwent 6-monthly skin tests (which included two recombinant proteins) until negative and annual skin tests thereafter. From the age of 8 years, the yearly follow-up was performed using the skin test that included two recombinant proteins, either until they became negative, developed active TB, or turned 18 years. Results: The annual incidence of TB in Russian children decreased from 19.1 per 100 000 population in 2001 to 8.3 per 100 000 population in 2018. Conclusions: Annual screening for TB exposure with treatment for latent or active TB has reduced the annual incidence of TB in Russian children aged 15–17 years to 1992 levels. Keywords: Latent tuberculosis, Screening of children and adolescents, Recombinant tuberculosis antigenhttp://www.sciencedirect.com/science/article/pii/S1201971220300965 |
| spellingShingle | Valentina Alexandrovna Aksenova Irina Anatolievna Vasilyeva Tereza Chermenovna Kasaeva Anastasia Gennadievna Samoilova Natalia Yurievna Pshenichnaya Tatyana Evgenievna Tyulkova Latent tuberculosis infection in children and adolescents in Russia International Journal of Infectious Diseases |
| title | Latent tuberculosis infection in children and adolescents in Russia |
| title_full | Latent tuberculosis infection in children and adolescents in Russia |
| title_fullStr | Latent tuberculosis infection in children and adolescents in Russia |
| title_full_unstemmed | Latent tuberculosis infection in children and adolescents in Russia |
| title_short | Latent tuberculosis infection in children and adolescents in Russia |
| title_sort | latent tuberculosis infection in children and adolescents in russia |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220300965 |
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