Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration
Abstract Introduction The aim of this study was to evaluate retinal and choriocapillaris (CC) vessel density, using optical coherence tomography angiography (OCTA), in the macular region at baseline and after three once-monthly intravitreal injections of bevacizumab (loading phase) in patients affec...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2019-10-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | http://link.springer.com/article/10.1007/s40123-019-00221-0 |
| _version_ | 1828771354555449344 |
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| author | Gilda Cennamo Daniela Montorio Anna D’Alessandro Pasquale Napolitano Luca D’Andrea Fausto Tranfa |
| author_facet | Gilda Cennamo Daniela Montorio Anna D’Alessandro Pasquale Napolitano Luca D’Andrea Fausto Tranfa |
| author_sort | Gilda Cennamo |
| collection | DOAJ |
| description | Abstract Introduction The aim of this study was to evaluate retinal and choriocapillaris (CC) vessel density, using optical coherence tomography angiography (OCTA), in the macular region at baseline and after three once-monthly intravitreal injections of bevacizumab (loading phase) in patients affected by exudative age-related macular degeneration (AMD). Methods A total 38 eyes of 38 patients with exudative AMD (16 women, 22 men; mean age 72.47 ± 7.46 years) were included in this study. We evaluated vessel density in different macular areas (whole image, fovea and parafovea) of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and CC. In addition, central macular thickness (CMT) and choroidal thickness in the foveal region and 500 µm in the nasal and temporal directions were analyzed by enhanced depth image-OCT. Results There were no significant differences in vessel density in the SCP, DCP and CC after the loading phase compared to baseline (p > 0.05). In contrast, CMT (p = 0.039; 320.63 ± 175.05 vs. 372.47 ± 167.05 µm) and subfoveal choroidal thickness (SFCT) (p < 0.001; 189.21 ± 37.66 µm vs 170.37 ± 37.96 µm) significantly decreased after the loading phase compared to baseline. No significant correlations were found between SFCT and CC vessel density in the fovea, and between CMT and SCP and DCP (p > 0.05) at baseline and after the loading phase. Also, best corrected visual acuity did not correlate with CMT, SCP and DCP at baseline and after treatment (p > 0.05). Conclusion Macular and choroidal thickness did not correlate with vessel density, but probably correlated to vascular exudation. The anti-VEGF treatment, acting on vascular hyperpermeability, determines the reduction of the retinal and choroidal exudation, resulting in a decrease of their thicknesses. Consequently, these parameters could reflect the effectiveness of the anti-VEGF injections for treating exudative AMD respect to OCTA parameters. Trial Registration ClinicalTrials.gov indentifier, NTC04138420. |
| first_indexed | 2024-12-11T14:23:38Z |
| format | Article |
| id | doaj.art-83ca454f629c4da0b30b70f3b00b8acd |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-12-11T14:23:38Z |
| publishDate | 2019-10-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-83ca454f629c4da0b30b70f3b00b8acd2022-12-22T01:02:47ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282019-10-0191778510.1007/s40123-019-00221-0Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular DegenerationGilda Cennamo0Daniela Montorio1Anna D’Alessandro2Pasquale Napolitano3Luca D’Andrea4Fausto Tranfa5Eye Clinic, Public Health Department, University of Naples Federico IIDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico IIDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico IIDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico IIDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico IIDepartment of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico IIAbstract Introduction The aim of this study was to evaluate retinal and choriocapillaris (CC) vessel density, using optical coherence tomography angiography (OCTA), in the macular region at baseline and after three once-monthly intravitreal injections of bevacizumab (loading phase) in patients affected by exudative age-related macular degeneration (AMD). Methods A total 38 eyes of 38 patients with exudative AMD (16 women, 22 men; mean age 72.47 ± 7.46 years) were included in this study. We evaluated vessel density in different macular areas (whole image, fovea and parafovea) of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and CC. In addition, central macular thickness (CMT) and choroidal thickness in the foveal region and 500 µm in the nasal and temporal directions were analyzed by enhanced depth image-OCT. Results There were no significant differences in vessel density in the SCP, DCP and CC after the loading phase compared to baseline (p > 0.05). In contrast, CMT (p = 0.039; 320.63 ± 175.05 vs. 372.47 ± 167.05 µm) and subfoveal choroidal thickness (SFCT) (p < 0.001; 189.21 ± 37.66 µm vs 170.37 ± 37.96 µm) significantly decreased after the loading phase compared to baseline. No significant correlations were found between SFCT and CC vessel density in the fovea, and between CMT and SCP and DCP (p > 0.05) at baseline and after the loading phase. Also, best corrected visual acuity did not correlate with CMT, SCP and DCP at baseline and after treatment (p > 0.05). Conclusion Macular and choroidal thickness did not correlate with vessel density, but probably correlated to vascular exudation. The anti-VEGF treatment, acting on vascular hyperpermeability, determines the reduction of the retinal and choroidal exudation, resulting in a decrease of their thicknesses. Consequently, these parameters could reflect the effectiveness of the anti-VEGF injections for treating exudative AMD respect to OCTA parameters. Trial Registration ClinicalTrials.gov indentifier, NTC04138420.http://link.springer.com/article/10.1007/s40123-019-00221-0Age-related macular degenerationBevacizumabChoroidal thicknessMacular thicknessOptical coherence tomography angiographySpectral domain-optical coherence tomography |
| spellingShingle | Gilda Cennamo Daniela Montorio Anna D’Alessandro Pasquale Napolitano Luca D’Andrea Fausto Tranfa Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration Ophthalmology and Therapy Age-related macular degeneration Bevacizumab Choroidal thickness Macular thickness Optical coherence tomography angiography Spectral domain-optical coherence tomography |
| title | Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration |
| title_full | Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration |
| title_fullStr | Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration |
| title_full_unstemmed | Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration |
| title_short | Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration |
| title_sort | prospective study of vessel density by optical coherence tomography angiography after intravitreal bevacizumab in exudative age related macular degeneration |
| topic | Age-related macular degeneration Bevacizumab Choroidal thickness Macular thickness Optical coherence tomography angiography Spectral domain-optical coherence tomography |
| url | http://link.springer.com/article/10.1007/s40123-019-00221-0 |
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