Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff base
The bivalent Co(II), Ni(II), Cu(II), and Zn(II) complexes (A, B, C, D) of novel Schiff base ligand such as 2-((E)-(5-(trifluoromethyl)-2-methoxyphenylimino)methyl)-4-chlorophenol (HL1) have been synthesized. The structural analysis have been carried by elemental analysis, NMR, FTIR, ESI-mass, UV–Vis...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623004708 |
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| author | M. Swathi Dasari Ayodhya Shivaraj |
| author_facet | M. Swathi Dasari Ayodhya Shivaraj |
| author_sort | M. Swathi |
| collection | DOAJ |
| description | The bivalent Co(II), Ni(II), Cu(II), and Zn(II) complexes (A, B, C, D) of novel Schiff base ligand such as 2-((E)-(5-(trifluoromethyl)-2-methoxyphenylimino)methyl)-4-chlorophenol (HL1) have been synthesized. The structural analysis have been carried by elemental analysis, NMR, FTIR, ESI-mass, UV–Visible, ESR, TGA and these results confirmed that Ni(II) and Cu(II) complexes were exhibit square planar geometry, whereas Co(II) and Zn(II) complexes exhibits octahedral geometry. DNA binding interaction studies such as UV absorption, viscosity, fluorescence techniques revealed that the mode of binding of complexes with DNA is intercalative mode. DNA cleavage studies revealed that all the complexes were cleaved into Form I & II. The pathological studies of all the complexes were screened against microbial strains in-vitro, which revealed that Cu(II) complexes are more potent compared to other complexes and free ligands. The antidiabetic and antioxidant activity studies revealed that Cu(II) complex exhibit slight higher activity. Cytotoxicity studies on cell lines (KB3 & MCF7 cell lines) revealed that the all synthesized complexes were showed superior activity compared to the ligand. |
| first_indexed | 2024-03-09T07:35:23Z |
| format | Article |
| id | doaj.art-83ca51759acd4c30bc07ea90d64fa70b |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-09T07:35:23Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-83ca51759acd4c30bc07ea90d64fa70b2023-12-03T05:41:07ZengElsevierResults in Chemistry2211-71562024-01-017101231Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff baseM. Swathi0Dasari Ayodhya1 Shivaraj2Department of Chemistry, Osmania University, Hyderabad, Telangana 500007, IndiaDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India; Chemical Group, Intellectual Property India, Patent Office, Guindy, Chennai, Tamil Nadu 600032, IndiaDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India; Corresponding author.The bivalent Co(II), Ni(II), Cu(II), and Zn(II) complexes (A, B, C, D) of novel Schiff base ligand such as 2-((E)-(5-(trifluoromethyl)-2-methoxyphenylimino)methyl)-4-chlorophenol (HL1) have been synthesized. The structural analysis have been carried by elemental analysis, NMR, FTIR, ESI-mass, UV–Visible, ESR, TGA and these results confirmed that Ni(II) and Cu(II) complexes were exhibit square planar geometry, whereas Co(II) and Zn(II) complexes exhibits octahedral geometry. DNA binding interaction studies such as UV absorption, viscosity, fluorescence techniques revealed that the mode of binding of complexes with DNA is intercalative mode. DNA cleavage studies revealed that all the complexes were cleaved into Form I & II. The pathological studies of all the complexes were screened against microbial strains in-vitro, which revealed that Cu(II) complexes are more potent compared to other complexes and free ligands. The antidiabetic and antioxidant activity studies revealed that Cu(II) complex exhibit slight higher activity. Cytotoxicity studies on cell lines (KB3 & MCF7 cell lines) revealed that the all synthesized complexes were showed superior activity compared to the ligand.http://www.sciencedirect.com/science/article/pii/S2211715623004708Coats redfern methodGeometrical optimizationThermodynamic parametersAnti-diabetic activityDNA interactionCytotoxicity study |
| spellingShingle | M. Swathi Dasari Ayodhya Shivaraj Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff base Results in Chemistry Coats redfern method Geometrical optimization Thermodynamic parameters Anti-diabetic activity DNA interaction Cytotoxicity study |
| title | Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff base |
| title_full | Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff base |
| title_fullStr | Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff base |
| title_full_unstemmed | Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff base |
| title_short | Design, structural characterization, DNA interaction studies, antibacterial, antioxidant, and cytotoxicity studies of Co(II), Ni(II), Cu((II), Zn((II) complexes containing 2-methoxy 5-trifluoromethyl benzenamine Schiff base |
| title_sort | design structural characterization dna interaction studies antibacterial antioxidant and cytotoxicity studies of co ii ni ii cu ii zn ii complexes containing 2 methoxy 5 trifluoromethyl benzenamine schiff base |
| topic | Coats redfern method Geometrical optimization Thermodynamic parameters Anti-diabetic activity DNA interaction Cytotoxicity study |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623004708 |
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