Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis
Tuberculosis (TB) is a virulent form of an infectious disease that causes a global burden due to its high infectivity and fatality rate, especially the irrepressible threats of latent infection. Constructing an efficient strategy for the prevention and control of TB is of great significance. Fortuna...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.845179/full |
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| author | Judun Zheng Xun Long Hao Chen Zhisheng Ji Bowen Shu Rui Yue Yechun Liao Shengchao Ma Kun Qiao Ying Liu Yuhui Liao Yuhui Liao Yuhui Liao |
| author_facet | Judun Zheng Xun Long Hao Chen Zhisheng Ji Bowen Shu Rui Yue Yechun Liao Shengchao Ma Kun Qiao Ying Liu Yuhui Liao Yuhui Liao Yuhui Liao |
| author_sort | Judun Zheng |
| collection | DOAJ |
| description | Tuberculosis (TB) is a virulent form of an infectious disease that causes a global burden due to its high infectivity and fatality rate, especially the irrepressible threats of latent infection. Constructing an efficient strategy for the prevention and control of TB is of great significance. Fortunately, we found that granulomas are endowed with higher reducibility levels possibly caused by internal inflammation and a relatively enclosed microenvironment. Therefore, we developed the first targeted glutathione- (GSH-) responsive theranostic system (RIF@Cy5.5-HA-NG) for tuberculosis with a rifampicin- (RIF-) loaded near-infrared emission carrier, which was constructed by photoclick reaction-actuated hydrophobic-hydrophobic interaction, enabling the early diagnosis of tuberculosis through granulomas-tracking. Furthermore, the loaded rifampicin was released through the dissociation of disulfide bond by the localized GSH in granulomas, realizing the targeted tuberculosis therapy and providing an especially accurate treatment mapping for tuberculosis. Thus, this targeted theranostic strategy for tuberculosis exhibits the potential to realize both granulomas-tracking and anti-infection of tuberculosis. |
| first_indexed | 2024-12-13T00:47:49Z |
| format | Article |
| id | doaj.art-83cb326e87694bcb82e81bfe2b84cbaa |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-13T00:47:49Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-83cb326e87694bcb82e81bfe2b84cbaa2022-12-22T00:04:59ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-02-01910.3389/fmolb.2022.845179845179Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-TuberculosisJudun Zheng0Xun Long1Hao Chen2Zhisheng Ji3Bowen Shu4Rui Yue5Yechun Liao6Shengchao Ma7Kun Qiao8Ying Liu9Yuhui Liao10Yuhui Liao11Yuhui Liao12Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Science and Education, The Third People’s Hospital of Bijie City, Bijie, ChinaDivision of Gastrointestinal Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, ChinaMolecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaMolecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Science and Education, The Third People’s Hospital of Bijie City, Bijie, ChinaNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, ChinaDepartment of Thoracic Surgery, Shenzhen Third People’s Hospital, Shenzhen, ChinaDepartment of Science and Education, The Third People’s Hospital of Bijie City, Bijie, ChinaMolecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, ChinaNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, ChinaDepartment of Infectious Disease, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaTuberculosis (TB) is a virulent form of an infectious disease that causes a global burden due to its high infectivity and fatality rate, especially the irrepressible threats of latent infection. Constructing an efficient strategy for the prevention and control of TB is of great significance. Fortunately, we found that granulomas are endowed with higher reducibility levels possibly caused by internal inflammation and a relatively enclosed microenvironment. Therefore, we developed the first targeted glutathione- (GSH-) responsive theranostic system (RIF@Cy5.5-HA-NG) for tuberculosis with a rifampicin- (RIF-) loaded near-infrared emission carrier, which was constructed by photoclick reaction-actuated hydrophobic-hydrophobic interaction, enabling the early diagnosis of tuberculosis through granulomas-tracking. Furthermore, the loaded rifampicin was released through the dissociation of disulfide bond by the localized GSH in granulomas, realizing the targeted tuberculosis therapy and providing an especially accurate treatment mapping for tuberculosis. Thus, this targeted theranostic strategy for tuberculosis exhibits the potential to realize both granulomas-tracking and anti-infection of tuberculosis.https://www.frontiersin.org/articles/10.3389/fmolb.2022.845179/fulltuberculosistheranostic systemphotoclick reactionmicroenvironmentglutathione |
| spellingShingle | Judun Zheng Xun Long Hao Chen Zhisheng Ji Bowen Shu Rui Yue Yechun Liao Shengchao Ma Kun Qiao Ying Liu Yuhui Liao Yuhui Liao Yuhui Liao Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis Frontiers in Molecular Biosciences tuberculosis theranostic system photoclick reaction microenvironment glutathione |
| title | Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis |
| title_full | Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis |
| title_fullStr | Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis |
| title_full_unstemmed | Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis |
| title_short | Photoclick Reaction Constructs Glutathione-Responsive Theranostic System for Anti-Tuberculosis |
| title_sort | photoclick reaction constructs glutathione responsive theranostic system for anti tuberculosis |
| topic | tuberculosis theranostic system photoclick reaction microenvironment glutathione |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.845179/full |
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