Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapy
A graphene quantum dots (GQDs) and manganese dioxide (MnO2) co-decorated, polydopamine (PDA) capped iron oxyhydroxide (FeOOH) nanorod was firstly constructed as a promising platform for magnetic resonance imaging (MRI) guided tumor synergistic therapy. Each component played an irreplaceable role. Tu...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522004166 |
| _version_ | 1818243816131395584 |
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| author | Meng Wang Gaojian Zhou Yuanjie Pan Yao Xue Shunhua Zhu Yuchen Yan Honghua Yuan Shibao Li Qingli Huang |
| author_facet | Meng Wang Gaojian Zhou Yuanjie Pan Yao Xue Shunhua Zhu Yuchen Yan Honghua Yuan Shibao Li Qingli Huang |
| author_sort | Meng Wang |
| collection | DOAJ |
| description | A graphene quantum dots (GQDs) and manganese dioxide (MnO2) co-decorated, polydopamine (PDA) capped iron oxyhydroxide (FeOOH) nanorod was firstly constructed as a promising platform for magnetic resonance imaging (MRI) guided tumor synergistic therapy. Each component played an irreplaceable role. Tumor microenvironment activated cascade Fenton catalytic activities and MRI capability at different stages were obtained, which can simultaneously realize diagnosis and chemodynamic therapy (CDT) for cancer. In addition, photothermal therapy (PTT) was also achieved owing to the excellent photothermal conversion efficiency of PDA and GQDs, which further improve the Fenton catalytic activities and realized synergistic therapy for cancer. The experimental results showed that only about 30% of cancer cells was killed when CDT or NIR laser alone for cancer inhibition. However, when PTT and CDT were employed simultaneously to treat the cancer cells, the therapeutic efficiency has increased by 300% (90% of cancer cells was killed and about 10% cancer cells survived) due to combinatorial effect of PTT and CDT. Obviously, a more effective treatment of cancer could be realized using MRI guided tumor synergistic therapy with the as-prepared nanocomposites. This study provides a proof of concept of design and construction of complex nanomaterials for cancer diagnosis and treatment. |
| first_indexed | 2024-12-12T14:07:08Z |
| format | Article |
| id | doaj.art-83ccd5d378fd4656805ef0206d858f40 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-12T14:07:08Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-83ccd5d378fd4656805ef0206d858f402022-12-22T00:22:12ZengElsevierMaterials & Design0264-12752022-07-01219110794Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapyMeng Wang0Gaojian Zhou1Yuanjie Pan2Yao Xue3Shunhua Zhu4Yuchen Yan5Honghua Yuan6Shibao Li7Qingli Huang8Public Experimental Research Center of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, ChinaThe First Clinical Medical College of Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaSchool of Pharmacy of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, ChinaPublic Experimental Research Center of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, ChinaMedical Technology School of Xuzhou Medical University, Xuzhou City, Jiangsu 221000, ChinaThe First Clinical Medical College of Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaPublic Experimental Research Center of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, ChinaMedical Technology School of Xuzhou Medical University, Xuzhou City, Jiangsu 221000, China; Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, China; Corresponding authors at: Public Experimental Research Center of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, China (Q. Huang). Medical Technology School of Xuzhou Medical University, Xuzhou City, Jiangsu 221000, China (S. Li).Public Experimental Research Center of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, China; School of Pharmacy of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, China; Corresponding authors at: Public Experimental Research Center of Xuzhou Medical University, Xuzhou City, Jiangsu 221004, China (Q. Huang). Medical Technology School of Xuzhou Medical University, Xuzhou City, Jiangsu 221000, China (S. Li).A graphene quantum dots (GQDs) and manganese dioxide (MnO2) co-decorated, polydopamine (PDA) capped iron oxyhydroxide (FeOOH) nanorod was firstly constructed as a promising platform for magnetic resonance imaging (MRI) guided tumor synergistic therapy. Each component played an irreplaceable role. Tumor microenvironment activated cascade Fenton catalytic activities and MRI capability at different stages were obtained, which can simultaneously realize diagnosis and chemodynamic therapy (CDT) for cancer. In addition, photothermal therapy (PTT) was also achieved owing to the excellent photothermal conversion efficiency of PDA and GQDs, which further improve the Fenton catalytic activities and realized synergistic therapy for cancer. The experimental results showed that only about 30% of cancer cells was killed when CDT or NIR laser alone for cancer inhibition. However, when PTT and CDT were employed simultaneously to treat the cancer cells, the therapeutic efficiency has increased by 300% (90% of cancer cells was killed and about 10% cancer cells survived) due to combinatorial effect of PTT and CDT. Obviously, a more effective treatment of cancer could be realized using MRI guided tumor synergistic therapy with the as-prepared nanocomposites. This study provides a proof of concept of design and construction of complex nanomaterials for cancer diagnosis and treatment.http://www.sciencedirect.com/science/article/pii/S0264127522004166NanocompositesCatalyticGraphene quantum dotsMagnetic resonance imagingSynergistic therapy |
| spellingShingle | Meng Wang Gaojian Zhou Yuanjie Pan Yao Xue Shunhua Zhu Yuchen Yan Honghua Yuan Shibao Li Qingli Huang Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapy Materials & Design Nanocomposites Catalytic Graphene quantum dots Magnetic resonance imaging Synergistic therapy |
| title | Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapy |
| title_full | Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapy |
| title_fullStr | Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapy |
| title_full_unstemmed | Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapy |
| title_short | Design and fabrication of cascade novel Fenton catalytic nanocomposite as theranostic agent for chemodynamic/photothermal synergistic tumor therapy |
| title_sort | design and fabrication of cascade novel fenton catalytic nanocomposite as theranostic agent for chemodynamic photothermal synergistic tumor therapy |
| topic | Nanocomposites Catalytic Graphene quantum dots Magnetic resonance imaging Synergistic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522004166 |
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