Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days
ABSTRACT The effect of the systemic absorption of 0.1% diclofenac sodium (DS) eyedrop was compared to that of 0.5% ketorolac tromethamine (KT) in female New Zealand white rabbits treated on both eyes three times a day for 90 days. The rabbits were divided in three groups of six animals (n= 18): KT g...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Minas Gerais
|
| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/abmvz/v71n6/0102-0935-abmvz-71-06-1865.pdf |
| _version_ | 1819180284567879680 |
|---|---|
| author | F.Q. Pereira B. Santos T. Carboni M. Bender D. Driemeier A.C.B. Cunha M.G. Biajoli F.B. Mello P.R. Silva J.A.T. Pigatto J.R.B. Mello |
| author_facet | F.Q. Pereira B. Santos T. Carboni M. Bender D. Driemeier A.C.B. Cunha M.G. Biajoli F.B. Mello P.R. Silva J.A.T. Pigatto J.R.B. Mello |
| author_sort | F.Q. Pereira |
| collection | DOAJ |
| description | ABSTRACT The effect of the systemic absorption of 0.1% diclofenac sodium (DS) eyedrop was compared to that of 0.5% ketorolac tromethamine (KT) in female New Zealand white rabbits treated on both eyes three times a day for 90 days. The rabbits were divided in three groups of six animals (n= 18): KT group, DS group, and control (Co) group, in which saline (0.9% NaCl) solution was instilled. Water and food consumption were measured daily, clinical examination was performed weekly, and blood samples were collected every 30 days for laboratory examination. The plasma was analyzed for the presence of KT and DS by solid-phase extraction (SPE) associated with mass spectrometry (MS). Systemic absorption of these drugs was confirmed by SPE-MS, allowing their separation and identification in the plasma. At the end of the treatment, the animals were euthanized and necropsied, and no macroscopic or microscopic changes were found. This observation confirmed the laboratory results, which were within normal reference standards for the species. According to the results obtained, it can be concluded that treatment with eyedrops containing KT and DS for 90 days in healthy rabbits does not cause adverse systemic effects. |
| first_indexed | 2024-12-22T22:11:54Z |
| format | Article |
| id | doaj.art-83cea5e7f13f45038ce6ac3b00f08c1b |
| institution | Directory Open Access Journal |
| issn | 1678-4162 |
| language | English |
| last_indexed | 2024-12-22T22:11:54Z |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj.art-83cea5e7f13f45038ce6ac3b00f08c1b2022-12-21T18:10:51ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-416210.1590/1678-4162-10219Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 daysF.Q. PereiraB. SantosT. CarboniM. BenderD. DriemeierA.C.B. CunhaM.G. BiajoliF.B. MelloP.R. SilvaJ.A.T. PigattoJ.R.B. MelloABSTRACT The effect of the systemic absorption of 0.1% diclofenac sodium (DS) eyedrop was compared to that of 0.5% ketorolac tromethamine (KT) in female New Zealand white rabbits treated on both eyes three times a day for 90 days. The rabbits were divided in three groups of six animals (n= 18): KT group, DS group, and control (Co) group, in which saline (0.9% NaCl) solution was instilled. Water and food consumption were measured daily, clinical examination was performed weekly, and blood samples were collected every 30 days for laboratory examination. The plasma was analyzed for the presence of KT and DS by solid-phase extraction (SPE) associated with mass spectrometry (MS). Systemic absorption of these drugs was confirmed by SPE-MS, allowing their separation and identification in the plasma. At the end of the treatment, the animals were euthanized and necropsied, and no macroscopic or microscopic changes were found. This observation confirmed the laboratory results, which were within normal reference standards for the species. According to the results obtained, it can be concluded that treatment with eyedrops containing KT and DS for 90 days in healthy rabbits does not cause adverse systemic effects.http://www.scielo.br/pdf/abmvz/v71n6/0102-0935-abmvz-71-06-1865.pdfrabbitseyedropsNSAIDsystemic absorption |
| spellingShingle | F.Q. Pereira B. Santos T. Carboni M. Bender D. Driemeier A.C.B. Cunha M.G. Biajoli F.B. Mello P.R. Silva J.A.T. Pigatto J.R.B. Mello Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days Arquivo Brasileiro de Medicina Veterinária e Zootecnia rabbits eyedrops NSAID systemic absorption |
| title | Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days |
| title_full | Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days |
| title_fullStr | Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days |
| title_full_unstemmed | Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days |
| title_short | Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days |
| title_sort | systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in new zealand rabbits for 90 days |
| topic | rabbits eyedrops NSAID systemic absorption |
| url | http://www.scielo.br/pdf/abmvz/v71n6/0102-0935-abmvz-71-06-1865.pdf |
| work_keys_str_mv | AT fqpereira systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT bsantos systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT tcarboni systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT mbender systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT ddriemeier systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT acbcunha systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT mgbiajoli systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT fbmello systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT prsilva systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT jatpigatto systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days AT jrbmello systemicabsortionandadverseeffectsoftopicalocularuseofketorolactromethamineandsodiumdiclofenacinnewzealandrabbitsfor90days |